Fig. 1 A high degree of epitope sharing and T cell promiscuity is observed between DQ8cis and DQ8trans for influenza and islet antigens. A high degree.

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Fig. 1 A high degree of epitope sharing and T cell promiscuity is observed between DQ8cis and DQ8trans for influenza and islet antigens. A high degree of epitope sharing and T cell promiscuity is observed between DQ8cis and DQ8trans for influenza and islet antigens. (A) A high degree of epitope overlap (highlighted in red) was observed between DQ8cis- and DQ8trans-restricted influenza-specific T cells. In contrast, only one DQ2cis-restricted epitope (HA102–118/HA108–124) was accommodated by DQ8cis/trans. Numbers indicate epitopes shared between DQ8cis, DQ2cis, and DQ8trans or exclusively presented by DQ8cis, DQ2cis, or DQ8trans. Each overlapping epitope (HA102–118/HA108–124, HA274–290/HA280–296, HA398–414/HA404–420, NP288–304/NP294–310, or NP480–496/NP486–498) was viewed as one epitope. (B and C) Cross-recognition of islet-specific clones was confirmed by T cell reactivity in the presence of 500 nM peptides. Black and white bars represent T cell reactivity stimulated by DQ8cis- and DQ8trans-transfected HEK293 cells, respectively. Error bars represent SDs among three experiments. SI, stimulation index. I-Ting Chow et al. Sci Adv 2019;5:eaaw9336 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).