Fig. 5. Effects of IL-9 blockade on chronic pulmonary inflammation

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Fig. 5. Effects of IL-9 blockade on chronic pulmonary inflammation Fig. 5. Effects of IL-9 blockade on chronic pulmonary inflammation. (A) Anti-IL-9 or control Iso IgG Ab were administered (100 µg/mouse, intraperitoneally) once a week throughout the OVA induced development of chronic asthma. Five weeks of OVA challenge induced massive infiltration of eosinophils, and anti-IL-9 treatment significantly suppressed their infiltration. (B) BALF from each experimental mouse was collected 24 hours after the final OVA challenge, and the number of cells in the BALF was determined. (C) Differential cell counts were calculated as (total cell number of BAL cells)×(percentage of mononuclear cells, eosinophils, or neutrophils counted in the Giemsa-stained cytospin cell preparation). MNC=mononuclear cell. (D) IL-9 blockade attenuated tissue inflammation. The randomly selected histologic images were scored as the mean inflammatory index, which represents the severity of peri-bronchial inflammation. Mucus producing goblet cells were visualized by PAS staining. Sections were stained with Sirius Red solution to detect collagen deposition. Images are presented at the original magnification of ×400. PAS-positive goblet cells and Sirius Red-positive sub-epithelial areas for each bronchiole were calculated using image analysis software for quantitative analysis. Data are expressed as the mean±SEM (n=5). *P<0.05; groups were compared as indicated using the Mann-Whitney U tests. OVA, ovalbumin; BALF, bronchoalveolar lavage fluid; IL, interleukin; PAS, periodic acid-Schiff; SEM, standard error of the mean. Fig. 5. Effects of IL-9 blockade on chronic pulmonary inflammation. (A) Anti-IL-9 or control Iso IgG Ab were administered (100 µg/mouse, intraperitoneally) once a week throughout the OVA induced development of chronic asthma. Five weeks of OVA challenge induced massive infiltration of eosinophils, and anti-IL-9 treatment significantly suppressed their infiltration . . . Allergy Asthma Immunol Res. 2013 Jul;5(4):197-206. http://dx.doi.org/10.4168/aair.2013.5.4.197