RNA Processing: Redrawing the Map of Charted Territory

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RNA Processing: Redrawing the Map of Charted Territory Anna Corrionero, Juan Valcárcel Molecular Cell Volume 36, Issue 6, Pages 918-919 (December 2009) DOI: 10.1016/j.molcel.2009.12.004 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 RNA Maps of Three Splicing Regulators RNA maps depict the correlation between sites of regulatory protein binding (determined by CLIP) relative to a model alternative exon and the outcome of splicing regulation (exon inclusion or skipping). Peaks represent regions with higher density of CLIP reads. Binding of Nova or Fox2 upstream of the exon correlates with exon skipping, whereas binding downstream of the exon correlates with inclusion. For PTB, skipping correlates with binding of the protein near the alternative exon, whereas inclusion correlates with binding near the distal, constitutive sites. (A) Nova RNA map. (B) Fox2 RNA map. (C) PTB RNA map. Molecular Cell 2009 36, 918-919DOI: (10.1016/j.molcel.2009.12.004) Copyright © 2009 Elsevier Inc. Terms and Conditions