Serotypes, genotypes and antimicrobial resistance patterns of human diarrhoeagenic Escherichia coli isolates circulating in southeastern China Y. Chen,

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Presentation transcript:

Serotypes, genotypes and antimicrobial resistance patterns of human diarrhoeagenic Escherichia coli isolates circulating in southeastern China Y. Chen, X. Chen, S. Zheng, F. Yu, H. Kong, Q. Yang, D. Cui, N. Chen, B. Lou, X. Li, L. Tian, X. Yang, G. Xie, Y. Dong, Z. Qin, D. Han, Y. Wang, W. Zhang, Y.-W. Tang, L. Li Clinical Microbiology and Infection Volume 20, Issue 1, Pages 52-58 (January 2014) DOI: 10.1111/1469-0691.12188 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Minimum spanning trees of 340 diarrhoeagenic Escherichia coli (DEC) sequence types (STs). The tree is based on the degree of allele sharing by MLST analysis, with different pathotypes of DEC (A), positivity and negativity for ESBL(B) and antimicrobial resistance (C). Each circle denotes a particular ST, and the size of the circle indicates the number of isolates of that particular type. Black lines connecting pairs of STs indicate that they share six (thick lines), five (thin) or four alleles (dash). Grey dotted lines connecting pairs of STs indicate that they share three to one alleles, with longer lines representing fewer shared alleles. Only predominant STs (≥ 7 isolates), ST678 and ST131 are marked. EAEC, enteroaggregative E. coli; ETEC, enterotoxigenic E. coli; EPEC, enteropathogenic E. coli; STEC, Shiga toxin-producing E. coli. Clinical Microbiology and Infection 2014 20, 52-58DOI: (10.1111/1469-0691.12188) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Heat map of antimicrobial resistance and ESBL genotype distribution across the predominant diarrhoeagenic Escherichia coli sequence types (STs) and serogroups. Darker shaded areas indicate a higher prevalence. AMP, ampicillin; MDR, multidrug resistant; CZO, cefazolin; SAM, ampicillin-sulbactam; TCY, tetracycline; SXT, trimethoprim-sulphamethoxazole; CXM, cefuroxime; CTX, cefotaxime; ESBL, extended-spectrum β-lactamase; GEN, gentamicin; AMC, amoxicillin-clavulanic acid; ATM, aztreonam; blaCTX-M, CTX-M β-lactamase gene; CIP, ciprofloxacin; FEP, cefepime; CAZ, ceftazidime; TZP, piperacillin-tazobactam; FOX, cefoxitin; AMK, amikacin; IPM, imipenem; MEM, meropenem. Clinical Microbiology and Infection 2014 20, 52-58DOI: (10.1111/1469-0691.12188) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions