Prevalence of Noncardiac and Genetic Abnormalities in Neonates Undergoing Cardiac Operations: Analysis of The Society of Thoracic Surgeons Congenital.

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Prevalence of Noncardiac and Genetic Abnormalities in Neonates Undergoing Cardiac Operations: Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database Angira Patel, MD, MPH, John M. Costello, MD, MPH, Carl L. Backer, MD, Sara K. Pasquali, MD, Kevin D. Hill, MD, MS, Amelia S. Wallace, MS, Jeffrey P. Jacobs, MD, Marshall L. Jacobs, MD The Annals of Thoracic Surgery Volume 102, Issue 5, Pages 1607-1614 (November 2016) DOI: 10.1016/j.athoracsur.2016.04.008 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Prevalence of noncardiac congenital anatomic abnormalities (NC), genetic abnormalities (GA), and syndromes (S) in neonates undergoing cardiac operations by diagnosis. (AVSD = atrioventricular septal defect; COA = coarctation of aorta/aortic arch hypoplasia; DORV = double-outlet right ventricle; HLHS = hypoplastic left heart syndrome; IAA = interrupted aortic arch; SV/Non-HLHS = single ventricle non–hypoplastic left heart syndrome; TA = truncus arteriosus; TAPVC = total anomalous pulmonary venous connection; TGA = transposition of the great arteries TOF = tetralogy of Fallot.) The Annals of Thoracic Surgery 2016 102, 1607-1614DOI: (10.1016/j.athoracsur.2016.04.008) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Prevalence of noncardiac (NC) abnormalities in neonates undergoing cardiac operations by diagnosis. aTotal N for each diagnosis further divided into n (%) for each NC abnormality; bunique neonates with any NC abnormality. (AVSD = atrioventricular septal defect; CDH = congenital diaphragmatic hernia; COA = coarctation of aorta/aortic arch hypoplasia; DORV = double-outlet right ventricle; HLHS = hypoplastic left heart syndrome; IAA = interrupted aortic arch; SV/Non-HLHS = single ventricle non–hypoplastic left heart syndrome; TA = truncus arteriosus; TAPVC = total anomalous pulmonary venous connection; TEF = tracheoesophageal fistula; TGA = transposition of the great arteries TOF = tetralogy of Fallot.) The Annals of Thoracic Surgery 2016 102, 1607-1614DOI: (10.1016/j.athoracsur.2016.04.008) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Prevalence of genetic and syndromic abnormalities (GA/S) in neonates undergoing cardiac operations by diagnosis. ∗Total N for each diagnosis further divided into n (%) for each noncardiac (NC) abnormality; ∗∗GA/S is specified, but total prevalence is n less than 7 (0.0% for the specific GA/S; ∗∗∗GA/S not specified, “other” box in database checked; ∗∗∗∗unique neonates with any GA/S abnormality. (AVSD = atrioventricular septal defect; CHARGE, coloboma, heart defect, atresia choanae, retarded growth and development, genital abnormality, and ear abnormality; COA = coarctation of the aorta/aortic arch hypoplasia; DORV = double-outlet right ventricle; HLHS = hypoplastic left heart syndrome; IAA = interrupted aortic arch; SV/Non-HLHS = single ventricle non -hypoplastic left heart syndrome; TA = truncus arteriosus; TAPVC, total anomalous pulmonary venous connection; TGA = transposition of the great arteries; TOF = tetralogy of Fallot; VACTERL = vertebral anomalies, anal atresia, cardiac defects, tracheoesophageal fistula and/or esophageal atresia, renal and radial anomalies and limb defects; WPW = Wolff-Parkinson-White syndrome.) The Annals of Thoracic Surgery 2016 102, 1607-1614DOI: (10.1016/j.athoracsur.2016.04.008) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions