Model of the change in receptor structure on engagement of the ligand IFN-γ. Model of the change in receptor structure on engagement of the ligand IFN-γ.

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Model of the change in receptor structure on engagement of the ligand IFN-γ. Model of the change in receptor structure on engagement of the ligand IFN-γ. When IFN-γ binds to the receptor complex, the distance between the IFN-γR1 and IFN-γR2 chains and the distance between the two IFN-γR2 chains increases. Opening the intracellular domain regions provides an opportunity for entry of components of the downstream signal transduction components. The distances and the changes in distances shown are not proportional to the actual measurements. Christopher D. Krause et al. Mol Cell Proteomics 2002;1:805-815 © 2002 The American Society for Biochemistry and Molecular Biology