Fig. 4 Orthosteric ligand-binding pocket in CysLT1R.

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Fig. 4 Orthosteric ligand-binding pocket in CysLT1R. Orthosteric ligand-binding pocket in CysLT1R. (A and D) Details of ligand-receptor interactions for pranlukast (A) and zafirlukast (D). (B and E) Pocket shapes for pranlukast (B) and zafirlukast (E). (C and F) Pocket entrance for pranlukast, closed “gate” (C), and zafirlukast, open “gate” (F). (G and H) 2D representations of receptor-ligand interactions for pranlukast (G) and zafirlukast (H). Water molecules are shown as red spheres in (A). Residues engaged in the same type of interactions with both zafirlukast and pranlukast are colored in light green, and those engaged in different types are colored in orange (G and H). The membrane boundary is shown as a dashed line in (B, C, E, and F). Aleksandra Luginina et al. Sci Adv 2019;5:eaax2518 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).