Scheme showing the secondary structure assignment of human PAH sequence (SWISS-PROT P00439). Scheme showing the secondary structure assignment of human.

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Scheme showing the secondary structure assignment of human PAH sequence (SWISS-PROT P00439). Scheme showing the secondary structure assignment of human PAH sequence (SWISS-PROT P00439). Secondary structure was assigned using the program DSSP56 on the composite PAH model.8 Residues that have PKU mutations associated with them are marked with grey dots. Secondary structural elements of the 3 regulatory domain are indicated as arrows for β-strands and coils for α-helical regions. Reprinted with permission from Erlandsen and Stevens.49 Heidi Erlandsen et al. Pediatrics 2003;112:1557-1565 ©2003 by American Academy of Pediatrics