Structure of an ATP-bound ABC dimer.

Slides:

Advertisements

Similar presentations

Structure of the Rho Transcription Terminator

Advertisements

Volume 9, Issue 7, Pages (July 2001)

Two functional states of human CFTR

Jue Chen, Gang Lu, Jeffrey Lin, Amy L Davidson, Florante A Quiocho

Volume 13, Issue 10, Pages (October 2005)

Cryo-EM image reconstruction of the 2D3/MNV complex fitted with the atomic models of the MNV P domain dimer and two of the MAb 2D3 Fabs. Cryo-EM image.

Volume 18, Issue 11, Pages (November 2010)

Inferring chromatin organization.

How Does Protein Architecture Facilitate the Transduction of ATP Chemical-Bond Energy into Mechanical Work? The Cases of Nitrogenase and ATP Binding-Cassette.

Po-Chao Wen, Emad Tajkhorshid Biophysical Journal

What Color is it?.

Insights into How Nucleotide-Binding Domains Power ABC Transport

Overview of predicted carbohydrate uptake and metabolism systems in bifidobacteria. Overview of predicted carbohydrate uptake and metabolism systems in.

Three-dimensional structure of B. subtilis PRPP synthase.

Allosteric site of B. subtilis PRPP synthase.

The microsporidian sex-related locus.

Solar spectrum in space (thin line) and on Earth's surface (thick line). Solar spectrum in space (thin line) and on Earth's surface (thick line). Below.

Volume 87, Issue 6, Pages (December 2004)

N-Glycosidic bond formation with PRPP

Danny N.P Doan, Terje Dokland Structure

Phrap assemblies visualized with the Consed (53) program.

Volume 90, Issue 1, Pages (July 1997)

Current models of the interactions of proteins within β-carboxysomes.

Catalytic strategies. Catalytic strategies. The coordination of Mg2+ (shown as blue spheres) of the active site to the substrates, to amino acid residues,

Schematic diagram of the proposed structure of CFTR

Schematic representation of major cell wall components.

Alignments of the complete genome sequences of the B

Volume 118, Issue 6, Pages (September 2004)

AMPK and SNF1: Snuffing Out Stress

Gymnastics of Molecular Chaperones

Crystal Structure of the Human Myeloid Cell Activating Receptor TREM-1

Representative protein structures for bacterial PPIases.

Helicase structures: a new twist on DNA unwinding

Model for T4P assembly. Model for T4P assembly. (A) Side view of the inner membrane assembly platform. In the pilus assembly cycle shown, a single pilin.

Summary of major events in Earth history relating to the appearance of eukaryotic groups and the appearance of O2 in the atmosphere and in marine environments.

Volume 29, Issue 1, Pages (January 2008)

Volume 10, Issue 1, Pages (July 2002)

Volume 13, Issue 4, Pages (April 2005)

Drug transport mechanism of AcrB.

Structures of P. aeruginosa ExoU and its chaperone, SpcU (PDB ID 3TU3), shown as a cartoon. Structures of P. aeruginosa ExoU and its chaperone, SpcU (PDB.

Schematic representation of the hydrolysis of amorphous and microcrystalline cellulose by noncomplexed (A) and complexed (B) cellulase systems. Schematic.

Antibiofilm strategies arising from fundamental research.

T4P gene clusters in C. perfringens and C. difficile.

Protein structures of various PFT classes.

Molecular model of C. pseudotuberculosis Smase D

Physiological effects of heat shock.

Simplified neighbor-joining tree of ABC domains.

Prophage genome map of the C. diphtheriae prophage encoding DT

Undecaprenyl-linked O antigen polysaccharide precursors (O-PS), initiated by a WecA homologue and elongated at the nonreducing end (black dots), are polymerized.

Structures of four importers.

Structure of an exporter.

Binding of mRNA to the 30S ribosomal subunit.

Simple CRP regulation operates through two related mechanisms, designated class I and class II. Both classes depend on specific interactions between CRP.

Concerted model for maltose transport.

Incorporation of new cell wall in differently shaped bacteria.

General scheme of the events triggered by C

Conserved motifs in the ABC

Absorption spectra of PRs in relation to light attenuation patterns in different marine environments. Absorption spectra of PRs in relation to light attenuation.

Thermodynamic cycle for ligand binding to a periplasmic-BP.

Schematic view of the organization of transport systems.

General overview of the bioinformatic pipelines for the 16S rRNA gene microbial profiling and shotgun metagenomics. General overview of the bioinformatic.

Splice isoforms of the JNK1, JNK2, and JNK3 proteins.

IF2 and structural homologues.

Sequence alignment of colicin lysis proteins.

Ribbon representations of GAP-oxidizing enzymes in Archaea.

TolA, TolB, and Pal crystal structures.

Models of pilus and pseudopilus fibers.

Acquisition of global regulators during the evolution of streptomycetes. Acquisition of global regulators during the evolution of streptomycetes. The multilocus.

A Dancer Caught Midstep: The Structure of ATP-Bound Hsp70

Molecular model of the Helicobacter pylori PldA1 dimer.

Presentation transcript:

Structure of an ATP-bound ABC dimer. Structure of an ATP-bound ABC dimer. The structure of a MalK homodimer with two ATPs bound (PDB accession no. 1Q12) is shown. Each NBD consists of two subdomains, a RecA-like subdomain (green) and a helical subdomain (blue). A C-terminal RD (not present in all ABC proteins) is shown in yellow. Corresponding domains in the second MalK subunit follow the same color scheme but are rendered in lighter colors. Two ATPs, represented as a ball-and-stick model, are bound between the NBDs. The Walker A motif is shown in red. Amy L. Davidson et al. Microbiol. Mol. Biol. Rev. 2008; doi:10.1128/MMBR.00031-07