A Wounded Nucleus Needs ESCRT Service

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A Wounded Nucleus Needs ESCRT Service Rosemarie Ungricht, Ulrike Kutay Developmental Cell Volume 37, Issue 3, Pages 202-204 (May 2016) DOI: 10.1016/j.devcel.2016.04.012 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Illustration of Selected ESCRT-Dependent Repair Processes (A) Migration of cells through narrow constrictions frequently causes rupturing of the NE with a concomitant loss of nuclear integrity. ESCRT-III and VPS4 are recruited to damaged sites for repair. (B) After chromosome segregation in mitosis, ESCRT-III and VPS4 help to seal the re-forming NE around chromatin. At sites of intersection between spindle microtubules and the NE, the AAA+ ATPase spastin supports microtubule severing. (C) Plasma membrane wounds, here caused by pore-forming toxins, are repaired by ESCRT-III. Developmental Cell 2016 37, 202-204DOI: (10.1016/j.devcel.2016.04.012) Copyright © 2016 Elsevier Inc. Terms and Conditions