Role of decreased baroreceptor sensitivity, and activation of RAAS and SNS in expansion of water and sodium retention as well as worsening HF. [Reprinted from J Am Coll Cardiol, vol. 47, Schrier RW, Role of diminished renal function in cardiovascular mortal... Role of decreased baroreceptor sensitivity, and activation of RAAS and SNS in expansion of water and sodium retention as well as worsening HF. [Reprinted from J Am Coll Cardiol, vol. 47, Schrier RW, Role of diminished renal function in cardiovascular mortality: Marker or pathogenetic factor? pp. 1–8, copyright 2006 (ref. 6), with permission from Elsevier.] Mohammad Sarraf et al. CJASN 2009;4:2013-2026 ©2009 by American Society of Nephrology