Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis (HD) patients. Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis.

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Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis (HD) patients. Effect of aspirin (ASA) on serum cytokine concentration in hemodialysis (HD) patients. Serum cytokine concentration were measured in HD patients using polymethylmethacrylate membranes before initiation of aspirin treatment (□) or after 2 (□) or 4 mo (▪) of aspirin treatment or one month after treatment was discontinued (checkered bars). Pretreatment IL-1β, IL-6, IL-8, and TNF-α were significantly higher than those in age-matched control subjects (shown with red horizontal line). Aspirin treatment reduced serum proinflammatory cytokines IL-6, IL-8, and TNF-α concentration, but only the change for TNF-α at 4 mo of aspirin treatment and 1 mo after treatment reached statistical significance (*P < 0.05) versus the control condition. The 1-mo posttreatment IL-10 level was significantly higher than all other IL-10 concentrations. Data are mean ± SE. Stuart L. Goldstein et al. CJASN 2006;1:979-986 ©2006 by American Society of Nephrology