Activated protein C inhibits chemotaxis and interleukin-6 release by human neutrophils without affecting other neutrophil functions H.F. Galley, N.E.

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Activated protein C inhibits chemotaxis and interleukin-6 release by human neutrophils without affecting other neutrophil functions H.F. Galley, N.E. El Sakka, N.R. Webster, D.A. Lowes, B.H. Cuthbertson British Journal of Anaesthesia Volume 100, Issue 6, Pages 815-819 (June 2008) DOI: 10.1093/bja/aen079 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 The effect of exposure of isolated human neutrophils to 100 ng ml−1 activated protein C (APC) on migration towards 1 nM interleukin-8 or 1 μM FMLP. Box and whisker plots are median, interquartile, and full range (n=10). British Journal of Anaesthesia 2008 100, 815-819DOI: (10.1093/bja/aen079) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 The effect of exposure on isolated human neutrophils to 2 μg ml−1 lipopolysaccharide (LPS) and 0–200 ng ml−1 activated protein C (APC) on (a) respiratory burst (NS) and (b) apoptosis (NS). Box and whisker plots are median, interquartile, and full range (n=10). British Journal of Anaesthesia 2008 100, 815-819DOI: (10.1093/bja/aen079) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 The effect of exposure on isolated human neutrophils to 2 μg ml−1 lipopolysaccharide (LPS) plus 0, 2, 20, or 200 ng ml−1 activated protein C (APC) on interleukin-6 (P=0.04) expression. In order to show individual trends, data are shown as a percentage of each IL-6 concentration in the absence of APC (n=10). Freidman analysis of variance P=0.04. British Journal of Anaesthesia 2008 100, 815-819DOI: (10.1093/bja/aen079) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions