Densin knock-out mice have normal gross neuroanatomy and low body weight. Densin knock-out mice have normal gross neuroanatomy and low body weight. A,

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* Figure A in S1 File Body weight (g) n=8/group

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Densin knock-out mice have normal gross neuroanatomy and low body weight. Densin knock-out mice have normal gross neuroanatomy and low body weight. A, At 3 weeks of age, densin knock-out mice had significantly lower body weights (6.8 ± 0.4 g, n = 15 mice) than wild-type mice (12.3 ± 0.5 g; n = 17 mice; ****p < 0.0001). By 11 weeks of age, the disparity in their weights was much less dramatic (wild-type, 27.1 ± 1.1 g, n = 21; densin knock-out, 23.9 ± 1.3 g; n = 19; p = 0.062). Significance was determined with two-tailed t test. Error bars represent SEM. B, Representative pictures of wild-type (left) and densin knock-out littermates (right) at 3 weeks of age. C, Representative Nissl-stained coronal sections from wild-type (left) and densin knock-out (right) mice (bregma −1.7 mm). Bottom row shows 5× images of the dentate gyrus. D, Immunohistochemical staining for GFAP is qualitatively similar in wild-type (left column) and knock-out (right column) sections. Representative images are shown of sensory cortex (top row) and the CA1 region of hippocampus (bottom row). Heterozygous, Het; Wt, wild type. Holly J. Carlisle et al. J. Neurosci. 2011;31:16194-16207 ©2011 by Society for Neuroscience