Increased immune reactivity to central nervous system–derived naturally presented peptides in patients with active multiple sclerosis Christine Riedhammer,

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Presentation transcript:

Increased immune reactivity to central nervous system–derived naturally presented peptides in patients with active multiple sclerosis Christine Riedhammer, Dagmar Halbritter, CLT, Robert Weissert, MD, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 2, Pages 694-696.e7 (February 2017) DOI: 10.1016/j.jaci.2016.08.015 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, No difference in specific IFN-γ–secreting cells for ligandome peptides between controls and the whole group of patients with MS. No significant difference was observed (P = .335, Mann-Whitney U test). Results of 51 different patients with MS were compared with results of 18 controls. B, Higher numbers of specific IFN-γ–secreting cells for ligandome peptides in patients with MS with active disease compared with inactive disease (P = .021, Mann-Whitney U test). Samples from 18 controls, 29 patients with MS with inactive disease, and 26 patients with active disease were tested (*P = .021, Mann-Whitney U test). Journal of Allergy and Clinical Immunology 2017 139, 694-696.e7DOI: (10.1016/j.jaci.2016.08.015) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Positive responses to tested eluted peptides from MHC molecules from the CNS of patients with MS are significantly higher in patients with active MS disease than in patients with inactive MS disease or controls. Numbers of IFN-γ–secreting cells exceeding the mean number of IFN-γ–secreting cells in negative control wells + 2 SD were considered a positive response. Samples from 18 controls, 29 patients with inactive MS disease, and 26 patients with active MS disease were tested. Patients with active MS disease showed a positive reaction to a median number of 3.5 peptides compared with a median number of 0.5 peptides in controls (P = .021, Mann-Whitney U test) and with a median number of 0 peptides in patients with inactive disease (*P = .003, Mann-Whitney U test). Journal of Allergy and Clinical Immunology 2017 139, 694-696.e7DOI: (10.1016/j.jaci.2016.08.015) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 No difference in specific IFN-γ–secreting cells for ligandome peptides in DR2b-positive and DR2b-negative individuals. Samples from 18 controls (among them 4 DR2b-positive and 14 DR2b-negative individuals), from 29 patients with inactive MS disease (10 DR2b-positive and 19 DR2b-negative), and from 26 patients with active MS disease (12 DR2b-positive and 14 DR2b-negative) were analyzed. Journal of Allergy and Clinical Immunology 2017 139, 694-696.e7DOI: (10.1016/j.jaci.2016.08.015) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions