Fig. 1 CPCB-RPE1 investigational implant.

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Presentation transcript:

Fig. 1 CPCB-RPE1 investigational implant. CPCB-RPE1 investigational implant. (A and B) Low-magnification (actual size 3.5 mm × 6.25 mm) (A) and high-magnification (B) color photographs of California Project to Cure Blindness–Retinal Pigment Epithelium 1 (CPCB-RPE1). Scale bar, 50 μm. (C) Schematic of the synthetic parylene substrate for human embryonic stem cell–derived RPE (hESC-RPE). The parylene membrane is 6 microns thick with submicrometer-thick circular regions and a smooth, nonporous anterior surface that promotes cell adherence and tightly spaced pattern of ultrathin circular regions that have molecular exclusion characteristics similar to Bruch’s membrane to facilitate nutrient and growth factor diffusion. Arrows show the bidirectional diffusion. Amir H. Kashani et al., Sci Transl Med 2018;10:eaao4097 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works