Figure 2 Involvement of plasmacytoid dendritic cells

Slides:

Advertisements

Similar presentations

Pathogen invasion MM Neutrophil DC PRR Naïve T cell CTL IFN-  B cell IgG IL-4, IL-5, IL-6 Th1 Th2 IgE IgA Cell lysis Tr cell IL-1 , TNF- , chemokines.

Advertisements

Immune Regulation and Tolerance

The life history of T lymphocytes Precursors mature in the thymus Naïve CD4+ and CD8+ T cells enter the circulation Naïve T cells circulate through lymph.

Infectious diseases Tissue transplantation Elimination of tumors Autoimmune diseases Gatekeeper function Sensing pathogens Priming adaptive immune responses.

PROFESSIONAL ANTIGEN PRESENTING CELLS

Chapter 15.  Immunological tolerance is defined as unresponsiveness to an antigen that is induced by previous exposure to that antigen  Antigens that.

M1 – Immunology CYTOKINES AND CHEMOKINES March 26, 2009 Ronald B

Dendritic Cells: Migration

B Cells and Antibodies Abul K. Abbas UCSF FOCiS.

Volume 72, Issue 6, Pages (September 2007)

Mononuclear phagocytes in Immune Defence

Immunological Tolerance and Autoimmune Diseases

Anifrolumab inhibits cytokine production, plasmacytoid dendritic cell (pDC) activation and the type I (interferon gene signature) IFN gene signature. Anifrolumab.

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Cell-mediated disease mechanisms of lupus nephritis

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 5 Involvement of B cells in SLE

Figure 1 Radiation-induced effects on tumour cells

Figure 1 Induction of immune tolerance

Lymphoid system.

Figure 2 Heat map of targeted therapies in autoimmune diseases

Differentiation and Functions of CD8+ Effector T Cells

Figure 2 Main functions of IL-1

Adaptive Immune System

Figure 1 Immune mechanisms in liver homeostasis

Figure 7 Defects in apoptosis

Figure 3 Nucleic acid sensors in SLE

Neutrophils, dendritic cells and macrophages deliver activation signals to marginal zone B cells. Neutrophils, dendritic cells and macrophages deliver.

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Nephrol. doi: /nrneph

Figure 3 TNFSF activities enhancing immune cell activation

Nat. Rev. Nephrol. doi: /nrneph

Figure 2 Schematic representation illustrating the journey

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Minyoung Her, MD, Arthur Kavanaugh, MD

Figure 4 Approaches to targeting inhibitory immune receptors

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

B-Cell-Directed Therapy for Inflammatory Skin Diseases

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 4 TNFSF inflammatory activities in tissue cells

during the alloimmune response

Figure 3 Biologics that attenuate effector responses in the kidney

Autoimmunity through Cytokine-Induced Dendritic Cell Activation

Figure 1 The current model of the pathogenesis of SLE

Bali Pulendran, Rafi Ahmed Cell

Nat. Rev. Nephrol. doi: /nrneph

Figure 2 GM-CSF — a key player in inflammation and autoimmunity

Nat. Rev. Rheumatol. doi: /nrrheum

Role of IgE in autoimmunity

Figure 1 Sequence of events in the development of autoimmune nephritis

A Hen in the Wolf Den: A Pathobiont Tale

Figure 2 Cellular contributions to the development of SLE

Tobias R. Kollmann, Ofer Levy, Ruth R. Montgomery, Stanislas Goriely

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 4 Role of chemokines in dendritic cell migration

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 The role of macrophages in RA

SLE: the many players involved in systemic autoimmunity and tissue destruction. SLE: the many players involved in systemic autoimmunity and tissue destruction.

IFNα Induces MDSC Maturation and Loss of Suppressive Function

The Biology of Intestinal Immunoglobulin A Responses

Sites and Stages of Autoreactive B Cell Activation and Regulation

Nat. Rev. Rheumatol. doi: /nrrheum

Jacques Banchereau, Virginia Pascual Immunity

Novel therapies target the principal components of the immune system that contribute to LN pathogenesis. Novel therapies target the principal components.

General overview of innate and adaptive immune responses to and regulation of black yeasts. General overview of innate and adaptive immune responses to.

Volume 27, Issue 5, Pages (November 2007)

Role of TACI during infection.

Presentation transcript:

Figure 2 Involvement of plasmacytoid dendritic cells in the induction and amplification of autoimmunity in systemic lupus erythematosus Figure 2 | Involvement of plasmacytoid dendritic cells in the induction and amplification of autoimmunity in systemic lupus erythematosus. Nuclear autoantigens (such as histones, ribonucleoproteins, Ro/SSA and La/SSB) complexed with autoantibodies are internalized via low-affinity immunoglobulin gamma Fc region receptor IIa (FcγRIIa) and induce type I interferon (IFN) production by plasmacytoid dendritic cells (pDCs) through engagement of endosomal Toll-like receptors. IFNs, in synergy with self DNA and self RNA complexes released by dying cells, induce the maturation of conventional dendritic cells (DCs). Activation of DCs induced by IFNs promotes the differentiation of CD8+ T lymphocytes into cytotoxic T lymphocytes (CTLs) and the polarization of CD4+ T cells into T helper type 1 (TH1) cells and TH17 cells. Cell lysis induced by CTLs generates nucleosomes and other autoantigens, whereas IL-17 fuels tissue damage by recruiting inflammatory cells. IFN-induced DC maturation also promotes the secretion of B cell activating factor (BAFF, also known as TNF ligand superfamily member 13B) and a proliferation-inducing ligand (APRIL, also known as TNF ligand superfamily member 13), which are involved in the survival of autoreactive plasma cells and the generation of autoantibodies. In the spleen, marginal zone B cells (MZ B cells) are essential for the maintenance of marginal zone macrophages (MZMs) that surround the splenic follicles. MZMs act as a follicular exclusion barrier against antigens derived from apoptotic cells, which is crucial in the induction and maintenance of tolerance. In SLE, pDCs accumulate in the marginal zone and their secretion of IFNs interferes with the crosstalk between MZ B cells and MZMs. This process leads to the follicular translocation of MZ B cells, the inability of MZMs to clear apoptotic cells and loss of tolerance to autoantigens. In the follicle, MZ B cells stimulate germinal centre (GC) reactions that result in autoantibody production. icDC, immature conventional dendritic cell; mcDC, mature conventional dendritic cell. Coutant, F. & Miossec, P. (2016) Altered dendritic cell functions in autoimmune diseases: distinct and overlapping profiles Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.147