CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis. CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis.

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CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis. CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis. (A) WT or Ccr6−/− mice were infected with C. albicans, and proliferation of oral TCRαβ+ cells was determined at day 2 after infection. Data are representative of three independent experiments. (B) Indicated mice were infected orally with C. albicans, and fungal burden was assessed by CFU enumeration on day 4 after infection. Bars represent the geometric mean. Each point represents an individual mouse. Dashed line represents the limit of detection (LOD; 30 CFU) (52). Data are compiled from four independent experiments. (C) WT mice were injected with 100 μg of anti-CCL20 antibodies or isotype controls on day −1 relative to infection. Proliferation of TCRαβ+ cells was determined on day 2 after infection. Data are representative of two experiments. For statistical analysis, Student’s t test or ANOVA was used. ****P < 0.0001. Akash H. Verma et al. Sci. Immunol. 2017;2:eaam8834 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works