ICEOS 2009, Istanbul Natural History of Spine in Patients with Esophageal Atresia -A Long-Term Population-Based Follow-up Study Ilkka Helenius, Saara J.

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Presentation transcript:

ICEOS 2009, Istanbul Natural History of Spine in Patients with Esophageal Atresia -A Long-Term Population-Based Follow-up Study Ilkka Helenius, Saara J Sistonen, Jari Peltonen, Risto J Rintala, Mikko P Pakarinen Turku and Helsinki Children’s Hospital, Turku and Helsinki, Finland E-mail: ilkka.helenius@helsinki.fi

Natural History of Spine in Esophageal Atresia. . . Author Relationships Disclosed Ilkka Helenius Pediatric Research Foundation (a) Medtronic (a,b) , Baxter (a) Saara Sistonen Pediatric Research Foundation (a) Jari Peltonen None Risto J. Rintala Pediatric Research Foundation (a) Mikko P. Pakarinen Pediatric Research Foundation (a) (a) Grants/Research Support (b) Consultant (c) Stock/Shareholder (d) Speakers’ Bureau (e) Other Financial Support 3rd ICEOS Authors Disclosure Information

Introduction Vertebral column malformations typically associate esophageal atresia (EA) (Lawhon et al. JBJS 1986) VATER association Vertebra, Anus, Trachea, Esophagus, Renis/Radius anomalies Thoracotomy during neonatal period increases further risk of scoliosis (Durning et al. JBJS 1980) One-fourth of patients with EA have vertebral anomalies (Keckler Ped Surg Int 2007) Natural history of scoliosis and vertebral anomalies in patients with EA unknown Esophageal atresia with tracheoesophageal fistula

Esophageal atresia repair Repair during neonatal period Right thoracotomy Tracheoesophageal fistula seclusion Primary Esophago-Esophagostomy

Methods 588 patients operated for EA in Helsinki Children’s Hospital between 1949 and 1985 were identified. 296 were alive and contacted in 2005. First 100 returning signed informed consent participated (Table 1). All patients had follow-up to adulthood, mean follow-up 36 yrs (21-57 yrs)

Study design Retrospective baseline data collection. All 100 patients underwent: - Physical examination of the spine - A standing PA spine radiograph - AP and lateral radiograph of c- spine - Questionnaire about skeletal symptoms Control population of 855 school children, if rib hump > 6 deg → Scoliosis radiograph (Nissinen 1993)

Patients Participants (n=100) Non-participants (n=161) Age (yrs) 36 (21-57) 37 (21-57) Males (%) 57 (57%) 84 (62%) Distal TE fistula 91 (91%) 120 (89%) VACTERL Primarily 5 (5%) 8 (5%) Currently 23 (23%)

Clinical findings 13 (13%) back or neck pain often at rest 54 (54%) showed rib hump ≥6 º 15 (15%) asymmetry of anterior thoracic wall

Vertebral anomalies 45 (45%) at least one vertebral anomaly. Cervical spine block vertebrae most common anomaly None with spine surgery

Results Vertebral anomalies Anomaly Number (%) Failure of segmentation Fused vertebrae 43 (43%) Unilateral bar 4 (4%) Failure of formation Wedge vertebrae 22 (22%) Butterfly 8 (8%) Hemivertebra 3 (3%)

Results Risk of scoliosis Patients Controls OR (95% CI) >10 degrees 56 (56%) 79 (9.2%) 13.2 (8.3-21) ≥25 degrees 11 (11%) 6 (2.4%) 37.8 (14-106) ≥45 degrees 1 (1%) 0

Risk factors for Scoliosis Multiple Logistic Regression Model Variable OR (95% CI) P value Gender 1.2 (0.6-2.9) 0.60 Heart surgery 2.0 (0.4-11) 0.40 Rib fusions 3.6 (0.7-19) 0.13 Any additional anomaly 2.1 (0.9-4.8) 0.07

Conclusions Risk of scoliosis 13-fold after repair of EA. Nearly half of patients present with vertebral anomalies, most commonly in cervical spine. Further assesment of cervical spine with full extension-flexion radiographs indicated to rule out instability.

Conclusions cont’d Associated anomalies most significant risk factor for scoliosis. Cervical vertebrae and esophagus anatomically adjacent structures, a local developmental defect in this area may underpin the synchronous occurrence of these anomalies. Spinal surgery rarely indicated, but due to high incidence routine screening of spine necessary

Thank you References Lawhon SM, MacEwan GD, Bunnell WP. J Bone Joint Surg 1986;68:424-9. Keckler SJ, Peter SD, Valusek PA, et al. Ped Surg Int 2007;23:309-13.