Cxxc1-deficient TH17 cells exhibit a Treg cell–like expression profile

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Fig. 1 TH17 cell differentiation was severely impaired in Cxxc1-deficient mice. TH17 cell differentiation was severely impaired in Cxxc1-deficient mice.

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Fig. 3 Cxxc1-deficient TH17 cells exhibit a Treg cell–like expression profile. Cxxc1-deficient TH17 cells exhibit a Treg cell–like expression profile. (A) Naive CD4+ T cells (CD4+CD25−CD62LhiCD44lo) from WT and RORγtcreCxxc1fl/fl mice were differentiated in the presence of TGF-β1 and IL-6 (TH17) for 72 hours, and the total RNA from the cells was analyzed by RNA-seq [STAR (structured transparent accessible reporting) method]. Scatter diagram showing changes in gene expression in WT and Cxxc1-deficient TH17 cells. Down-regulated genes are indicated in blue; up-regulated genes are indicated in red. (B) Heatmap of the fold change (log2) for differentially expressed genes (false discovery rate < 0.05 in TH17 cells is shown). (C) Pathway analysis of the down-regulated genes (left) and up-regulated genes (right). (D) The expression of the selected transcripts was quantified in TH17 cell samples differentiated from naive CD4+ T cells with TGF-β1 and IL-6 for 72 hours by real-time qPCR. One of five experiments is shown. Error bars show the means ± SD. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 using the Student’s t test. Feng Lin et al. Sci Adv 2019;5:eaax1608 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).