CSGG-induced iTreg cells are capable of suppressing intestinal inflammation. CSGG-induced iTreg cells are capable of suppressing intestinal inflammation.

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CSGG-induced iTreg cells are capable of suppressing intestinal inflammation. CSGG-induced iTreg cells are capable of suppressing intestinal inflammation. (A to D) Naïve CD4+Foxp3− T cells sorted from Thy1.1+Foxp3GFP reporter mice were adoptively cotransferred into Rag1−/− recipients in indicated combinations of iTreg cells or nTreg cells. Changes in body weight, colon length, histopathology, and histological score of colonic tissue were measured. (E) Analysis of the Foxp3 stability of transferred Treg cells in the cLP at the end of the experiment. At the time of transfer, the purity of the sorted CD4+Foxp3GFP+ cells was more than 98%. (F to H) Naïve CD4+Foxp3− T cells sorted from CD45.1+Foxp3GFP reporter mice were adoptively transferred into Rag1−/− mice, followed by intraperitoneal administration of PBS or CSGG (100 μg/ml). Changes in body weight, colon length, histopathology, and histological score in colonic tissue were measured. (I) Analysis of the IFNγ-producing effector T cells in cLP at the end of the experiment. Data are representative of at least three independent experiments with similar results (n ≥ 3 mice). Graphs with error bars show means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (Student’s t test). Ravi Verma et al. Sci. Immunol. 2018;3:eaat6975 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works