Schematic diagram of the concept of hypoglycemia-associated autonomic failure and the pathogenesis of the syndromes of defective glucose counterregulation and hypoglycemia unawareness in type 1 diabetes.3. Schematic diagram of the concept of hypoglycemia-associated autonomic failure and the pathogenesis of the syndromes of defective glucose counterregulation and hypoglycemia unawareness in type 1 diabetes.3 Philip E. Cryer, and Belinda P. Childs Diabetes Spectr 2002;15:20-27 ©2002 by American Diabetes Association