Relative risk by median risk exposure for 40-year-old men. Relative risk by median risk exposure for 40-year-old men. A) The sliders reflect age (range 20–80 yr), exposure level for each risk (range 10th–90th percentile, reflecting percentile exposure level in the total population) and sex-specific algorithm (male, female). B) Point estimate (red dot) and 95% confidence interval (blue line) of 5-year relative risk of cardiovascular event by exposure variable. Reference group for continuous variables = lower number from exposure slider (10th percentile in this example), with the exception of smoking, where reference group = nonsmoker. Reference group for categorical variables = pink dot. C) Visualization for impact of age interaction and exposure level on relative risk for selected exposure: y-axis = relative risk, x-axis = age or percentile exposure. In this example, selected exposure = current smoker, age = 40, percentile exposure for pack-years = 50th. Blue line represents range of relative risk by age or percentile of exposure. See www.projectbiglife.ca for an interactive version of this figure. BMI = body mass index. Douglas G. Manuel et al. CMAJ 2018;190:E871-E882 ©2018 by Canadian Medical Association