Fig. 2 Astrocyte-specific AAV2/5 RiboTag.

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Fig. 2 Astrocyte-specific AAV2/5 RiboTag. Astrocyte-specific AAV2/5 RiboTag. (A) Astrocyte-specific RNA-seq from HD mice. (B and C) IHC images of 6-month WT dorsolateral striatum as control for Q175 (B) and 2-month NCAR dorsolateral striatum as control for R6/2 mice (C). (D and E) % of S100β+ or NeuN+ cells that colocalized with Rpl22-HA for WT, Q175 (D), NCAR, and R6/2 mice (E) (n = 3 mice). (F and G) Gene expression (in FPKM) of brain cell–type markers in WT (F) and NCAR (G). (H and I) Relative RNA-seq expression (z score) of the top 200 adult striatum astrocyte-enriched genes [enriched in IP versus input with FPKM > 10 (18)] (H) or whole-striatum–enriched genes (depleted in IP versus input) (I) in WT and NCAR samples. (J and K) PCA of WT and Q175 at 2, 6, and 12 months (J) or NCAR and R6/2 at 1, 2, and 3 months (K). RNA-seq was performed in four replicate mice. Open circles are raw data, with closed circles indicating mean ± SEM. Blanca Diaz-Castro et al., Sci Transl Med 2019;11:eaaw8546 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works