Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September.

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Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Design of a facility to host experiment mice in space MDS Gabriele Baronio, Giancarlo Falcetti, Stefano Uberti, Valerio Villa Mice Drawer System

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September MDS Device to host a colony of 6 mice in space (on board of ISS). Available commercial space (rack) with given interfaces. Functions: to feed, to water, administer controlled dosages of drugs, remove excrements, environmental conditioning. 6 separate cages without contacts between mice. Needs: guarantee mices physic and psychic well-being to have realistic results in experiments.

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Box: 440.1x253.2x516.1 [mm] 12mm insulation, only on lateral walls. Design targets Max dimensions Animals contained 6 Mice30-40 days/mouse Permanence in space 90 day between launch and landing Rack Panel connection Switch on/off, Led, Data connector, Power connector, Air in filter, Air out filter, Water refilling connector, Food refilling opening

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Needs Air Water Food Dry food x 100 days 3 Kg Reservoir (2-3l) + Pump + pipes Filters in/out + Pump + Manifold + Vent-hole Food tablet LHU (Liquid Handling Unit) Drug reservoir + Electrovalves + Metering pump Dimensions Vmin=650 cm^3/mouse Consumption: 20-30% mouses weight/day 6 cages + den max available surface

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Climatic control Insulation Environment control Cleaning Food reminder and excrements removing Mobile camera Filters Management and ControlElectronic unit camera + guide + motor Temperature Humidity Desiccator Heat exchanger Decease management ? Bacteriological in & out Biological/microbiological Filters

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Heat exchanger Electronic unit Materials Water and food Up/Dow n Biological/micr o-biological Insulation Containers Rack panel Lateral walls with insulation Available space

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Breadboard

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Cages study

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September MDS Cages details

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Mouses habitat

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Final cage + Food handling

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Simple Sandwich type assembling

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Experiment container

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Liquid handling

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September LHU Liquid Handling Unit

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Drugs and water handling

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September LHU can be distributed as we need, because it is pipe-connected and not rigid

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Comparison between hypothesis Building elements

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September Breadboard building

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September

Università degli Studi di Brescia Dipartimento di Ingegneria Meccanica Mice Drawer System G. Baronio, G. Falcetti, S. Uberti, V. Villa AED Glasgowi, September thank you