MNW leerlijn Bioinformatics Bioinformatics & Systems Biology Faculty of Sciences & Faculty of Earth and Life Sciences Jaap Heringa – 12 sep 2011.

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Presentation transcript:

MNW leerlijn Bioinformatics Bioinformatics & Systems Biology Faculty of Sciences & Faculty of Earth and Life Sciences Jaap Heringa – 12 sep 2011

Teachers (Bioinformatics & Systems Biology) dr. Sanne Abeln (UD Bioinformatics) dr. Anton Feenstra (UD Bioinformatics) prof. dr. Jaap Heringa (Prof. Bioinformatics) dr. Frank Bruggeman (UD Systems Biology) dr. Douwe Molenaar (UHD Systems Bioinformatics) prof. dr. Bas Teusink (Prof. Systems Bioinformatics) - the people

From anatomy to dynamics to systems biology and bioinformatics time  Statics, anatomy, architecture  Dynamics, mechanics  Informatics (Cybernetics – Wiener, 1948) (Cybernetics has been defined as the science of control in machines and animals, and hence it applies to technological, animal and environmental systems)  Genomics, bioinformatics, systems biology

Bioinformatics & Systems Biology as interdisciplinary sciences Mathematics Statistics Computer Science Informatics Biology Molecular biology Medicine Chemistry Physics Bioinformatics & Systems Biology

Bioinformatics & Systems Biology The big bang…

The Human Genome Project

From DNA… OH BRAD,THEY SAY THERE’S DNA IN MY BODY! WHO CARES, DARLING,...WHO CARES acctc ctgtgcaag acatgaaaca cccgatttac nctgtggttc cccagatgg gtcctgtccc aggtgcacct gcaggagtcg gcccaggac tggggaagcc tccagagctc aaaaccccac tggtgacac aactcacaca tgcccacggt gcccagagcc aaatcttgt gacacacctc ccccgtgccc acggtgccca agcccaaat cttgtgacac acctccccca tgcccacggt cccagagcc caaatcttgt gacacacctc ccccgtgccc cggtgccca gcacctgaac tcttgggagg accgtcagtc tcctcttcc ccccaaaacc caaggatacc cttatgattt ccggacccc tgaggtcacg tgcgtggtgg tggacgtgag cacgaagac cctnnngtcc agttcaagtg gtacgtggac gcgtggagg tgcataatgc caagacaaag ctgcgggagg gcagtacaa cagcacgttc cgtgtggtca gcgtcctcac gtcctgcac caggactggc tgaacggcaa ggagtacaag gcaaggtct ccaacaaagc aaccaagtca gcctgacctg ctggtcaaa ggcttctacc ccagcgacat cgccgtggag gggagagca atgggcagcc ggagaacaac tacaacacca gcctcccat gctggactcc gacggctcct tcttcctcta agcaagctc accgtggaca agagcaggtg gcagcagggg acatcttct catgctccgt gatgcatgag gctctgcaca ccgctacac gcagaagagc ctctc.....

It’s the network stupid!

next generation sequencing (baseclear) mammaprint (agendia) Research in Bioinformatics model + algoritme clinical trials (chdr)

Theme 1: Sequence based research

Reversible oligomerization Irreversible fiber formation Theme 2: Structure based research

Theme 3: Function based research the network level

Een revolutie in de biologie…

Bioinformatics & Systems Biology data knowledge hoe gaan we die data organiseren en gebruiken? Hoe gaan we om met de complexiteit van biologische systemen?

Systeembiologie is de biologie van de toekomst…

Bioinformatics and Systems Biology Bioinformatica probeert biologische componenten te interpreteren (labelen) voorspel structuur of functie van een eiwit reconstueer netwerk topologie er is meestal geen tijdscomponent Systeembiologie probeert de processen door de tijd te begrijpen meestal op netwerkniveau

Contact Master Bioinformatics Jaap Heringa Sanne Abeln Anton Feenstra Bas Teusink Douwe Molenaar

Click to edit the outline text format Second Outline Level  Third Outline Level Fourth Outline Level  Fifth Outline Level  Sixth Outline Level  Seventh Outline Level  Eighth Outline Level Ninth Outline LevelClick to edit Master text styles Second level Third level Fourth level Fifth level END