Review Article Acute Pulmonary Embolism

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Presentation transcript:

Review Article Acute Pulmonary Embolism Victor F. Tapson, M.D. N Engl J Med Volume 358(10):1037-1052 March 6, 2008

Summary Acute pulmonary embolism may occur rapidly and unpredictably and may be difficult to diagnose. Treatment can reduce mortality, and appropriate primary prophylaxis is usually effective. This review focuses on the pathogenesis, diagnosis, and treatment of acute pulmonary embolism of thrombotic origin.

Outline Epidemiology and Pathophysiology Risk Factors Acquired Risk Factors Genetic Disorders and Thromboembolic Risk Diagnostic Approaches Clinical Manifestations Preliminary Laboratory Testing and Pretest Probability Imaging Studies Treatment Anticoagulation Placement of a Vena Caval Filter Treatment of Massive Pulmonary Embolism Complications of Thrombolytic Therapy Prognosis Prevention Pregnancy and Acute Pulmonary Embolism Conclusions

Pathophysiology of Pulmonary Embolism Tapson V. N Engl J Med 2008;358:1037-1052

Risk Factors for Venous Thromboembolism Tapson V. N Engl J Med 2008;358:1037-1052

Clinical Prediction Scores for Suspected Acute Pulmonary Embolism Tapson V. N Engl J Med 2008;358:1037-1052

Contrast-Enhanced CT Angiograms Showing Acute Pulmonary Embolism Tapson V. N Engl J Med 2008;358:1037-1052

Diagnostic Approach to Suspected Acute Pulmonary Embolism Tapson V. N Engl J Med 2008;358:1037-1052

Treatment of Acute Pulmonary Embolism Tapson V. N Engl J Med 2008;358:1037-1052