Thick mucus in airways and lungs and breathing problems Chronic lung infections Digestive problems that lead to poor growth Increased salty sweat What are the symptoms observed in Cystic Fibrosis Patients? XXXX

Non-carrier of CF CF patient Carrier of CF CC Cc cc Genotype Nomenclature What is the carrier status? XXXX

Ethical Legal Social Implications E L S I What Do the letters in ELSI stand for? XXXX

It stands for cystic fibrosis transmembrane conductance regulator It functions as a chloride ion channel It is localized to the plasma membrane Cystic fibrosis is caused by a mutation in the CFTR gene There are over 400 different mutations known for CFTR gene What do you know about CFTR XXXX

Traps dust, dirt, germs in the lining of your nose, trachea and lungs Tiny hairs that push mucus out of your lungs and into your throat Mucus glands The system of mucus and cilia that rids our lungs of bacteria What does mucus do? What are cilia? Where is mucus made? What is the mucociliary escalator? There are over 400 different mutations known for CFTR gene What is different about the mucus of people with CF? Mucus, Mucus, Mucus XXXX

Water is drawn into our cells Channels Water is drawn out of the cell Osmosis If the concentration of chloride ions is higher inside the cell? How does it cross the cell membrane? If the concentration of chloride ions is higher outside the cell? What is the process of water following the concentration gradient called? What about water inside our cells? XXXX

On the chromosome In the cell nucleus Cell cytoplasm CFTR messenger RNA Where is the CFTR gene found Where does transcription occur? Where does translation occur? What is the CFTR gene transcribed into? CTFR protein What is the CFTR mRNA translated into? XXXX Making CFTR Protein