General Presentation v.2

Introduction Biochemize S.L. Biochemize S.L. is a biotechnological company focused in the design and development of processes based on biocatalysis. Our technological platform lies in the use of enzymes or microorganisms to perform chemical reactions able to substitute manufacturing processes based on classical organic chemistry.

General Presentation v.2 Location We are located in Terrassa, at 20 km from Barcelona. Our office and laboratories are part of the facilities of the Technology Centre of our associate partner Leitat.

General Presentation v.2 Our Technology Biochemize S.L. Biochemize S.L. develops bioprocesses using biocatalysts (enzymes or microorganisms) in single or multiple transformation steps. P2B Our technological platform P2B (Platform to Biochemize) is capable to perform high throughput screening of biocatalysts, reaction conditions, suitable substrates and products obtained. The screening can be done in a short period of time and renders information about different possible bioprocesses and conditions that could be further developed at a larger scale.

General Presentation v.2 P2B – Platform To Biochemize P2B P2B is the key to determine quickly with low risk and at very small scale if a conceptual biotransformation is technologically viable. Biochemize S.L. Once the succeeding biocatalysts or bioprocesses have been identified, Biochemize S.L. investigates at lab scale the experimental conditions which can lead to the highest yields. Two approaches can be followed: P2B Bioprocess Development of bioprocesses suitable to substitute already established synthetic procedures up to an industrial scale Perform biotransformations that can lead to a (new) chemical entity with improved features compared to the starting molecule P2B Discovery

General Presentation v.2 P2B – Platform To Biochemize P2B-Bioprocess The information obtained from P2B-Bioprocess allows estimations of productivity, costs and risks needed to confirm whether the process is feasible at industrial scale. P2B Lab Scale Screening of biocatalysts & conditions Catalyst selection & conditions optimization Feasibility Estimation of Productivity, Costs & Risks Industrialization

General Presentation v.2 Products & Services Biochemize S.L. Biochemize S.L. offers the following contract research services to customers: Technical Assessments and Consulting Development of biotechnology processes Obtaining building blocks Support in discovery of new chemical entities

General Presentation v.2 Products & Services We offer theoretical evaluations and consulting to verify the feasibility of substituting chemical synthetic processes by biotechnology. (Experimental work is also possible) Technical Assessments and Consulting The assessments include estimations of yields, engineering needs, costs, risks, regulatory aspects, etc. Biochemize S.L. Biochemize S.L. has a worldwide network of contacts: suppliers of biocatalysts, manufacturers, analytical services, researcher, advisors, etc. We offer consulting and contact extension possibilities to customers through our own network.

General Presentation v.2 Products & Services Substitution of processes based on synthetic organic chemistry by biotechnology. Development of biotechnology processes ABCD A Bioprocess can be more efficient, costs saving or less contaminant A Bioprocess can be highly selective. Sometimes allows reducing synthetic pathways (e.g. protection/deprotection steps) Biochemize S.L. The development ranges from theoretical design to industrial scale-up and implementation. This latter phase is carried out by the customer under the support and supervision of Biochemize S.L.

General Presentation v.2 Products & Services Building blocks can help to reduce synthesis steps of current processes or skipping reagents or intermediates hazardous, unstable, or complex to be obtained. Obtaining of building blocks Building blocks obtained by biotechnology can be used as alternative source of reagents, starting materials and intermediates for chemical synthesis.

General Presentation v.2 Products & Services Synthesis of potential new chemical entities through biotechnology approaches. Biocatalysts can be used to obtain new lead, lead optimization, me-too and me-better compounds by modification of already available structures. Strategy especially interesting for molecules of natural origin and/or complex structure. Support in discovery of new chemical entities Biotechnological transformations can be applied to obtain a new molecule without complex synthetic processes or avoiding the use of synthetic reagents that can deeply change the original structure. Biochemize S.L.P2B Biochemize S.L. can perform High Throughput Screening through the P2B technology.

General Presentation v.2 Operations Biochemize S.L. Biochemize S.L. offers the most outstanding and up to date technology options, while maintaining an industrial scope. If necessary, many operations can be outsourced to other companies and research centres under our direction and supervision. We have a powerful network of contacts in biocatalysis and bioprocessing. Several partnership agreements have been established. Austria Bulgaria China Denmark Ireland Italy Korea Netherlands Spain United Kingdom United States Advisors Analytical Services Biocatalyst Suppliers Bioprocessing Services Biotransformation Experts Enzyme Screening Enzyme Immobilization Genetic Engineering Manufacturers Research & Development Scaling-Up Services

General Presentation v.2 Operations Biochemize S.L. Biochemize S.L. is able to perform many biocatalyzed transformations. Our most recent experience is based on the following reactions: Amide Formation, Hydrolysis, Hydration & dehydration Nitrile Formation & hydrolysis Ester Formation & hydrolysis Oxidation & Reduction Aldol reaction Transamidation Transesterification

General Presentation v.2 Project Management Biochemize S.L. Biochemize S.L. follows a project management approach which comprises several development phases: PHASE IIPHASE IIIPHASE IVPHASE VPHASE I Experimental Exploratory Research Technology Development Scale-Up Industrial Implement. Theoretical Evaluation Biotransform. Screening Biocatalyst Selection & Reproduction Compound Characteriz. Small Scale Production Bibliography Assessment P2BDiscovery P2BBioprocess Each phase is not planned nor quoted until the previous phase is not completed and the results presented. Control of Risks and Costs: The customer decides the project continuation at each phase depending on results and conclusions obtained so far.

General Presentation v.2 Why contracting Biochemize? We offer the most outstanding and up to date technology options. Industrial scope guaranteed: productivity, costs and risks are the key drivers of our evaluations. P2B Our technology platform (P2B) is a powerful tool for fast, low risk and small scale proof of concept verifications. P2B We increase the success possibilities through the P2B platform and our network of contacts. Project management based on a development by phases approach. The customer controls the risks and costs associated to the project development.

General Presentation v.2 Contact Jaume Mir Founder CEO and Commercial Director Telephone: Address:C/. de la Innovació, 2 (Leitat Centre Tecnològic) – Terrassa (Barcelona) SPAIN

General Presentation v.2