Cytidine analogue ALL, AML cytarabine (araC) Cytidine analogue ALL, AML

Guanine analogue AML Watch myelosuppression and GI perforation thioguanine Guanine analogue AML Watch myelosuppression and GI perforation

cyclophosphamide Alkylating agent (binds DNA) Autoimmune diseases, leukemias/lymphomas Beware hemorrhagic cystitis

vinblastine Prevents microtubule polymerization Metastatic testicular cancer and lymphoma Marrow suppression is dose-limiting

Alkylating agent Hodgkin’s disease dacarbazine Alkylating agent Hodgkin’s disease

irinotecan Topoisomerase I inhibitor Colorectal cancer Beware life-threatening diarrhea

Alkylating agent Hodgkin’s disease procarbazine Alkylating agent Hodgkin’s disease

Thymidylate synthase inhibitor Breast, GI, and skin cancer (topical) 5-FluoroUracil Thymidylate synthase inhibitor Breast, GI, and skin cancer (topical)

bleomycin Breaks DNA via oxidative intermediaries Testicular cancer and hodgkin’s disease Pulmonary fibrosis is dose-limiting

Alkylating agent gastric and pancreatic cancer mitomycin Alkylating agent gastric and pancreatic cancer

Thymidylate synthase inhibitor Metastatic colorectal and breast cancer capecitabine Thymidylate synthase inhibitor Metastatic colorectal and breast cancer

Topoisomerase II inhibitor Leukemias and lymphomas Watch heart failure doxorubicin Topoisomerase II inhibitor Leukemias and lymphomas Watch heart failure

hydroxyurea Inhibits ribonucleotide reductase Hematologic malignancies, head & neck cancers, sickle cell (increases HbF) Watch out for secondary leukemia

Alkylating agent Brain cancer carmustine Alkylating agent Brain cancer

6-MercaptoPurine Inhibitor of IMP dehydrogenase (purine construction) ALL, AML Allopurinol potentiates effectiveness and pancreatic/marrow toxicity

azathioprine Inhibitor of IMP dehydrogenase (purine construction) Immunosuppression in renal transplants, RA Allopurinol potentiates effectiveness and toxicity

etoposide Topoisomerase II inhibitor Testicular and lung cancer Watch myelosuppression

Alkylating agent Ovarian cancer altretamine Alkylating agent Ovarian cancer

Alkylating agent Bladder cancer (instilled directly into bladder) thiopeta Alkylating agent Bladder cancer (instilled directly into bladder)

vincristine Prevents microtubule polymerization Leukemias and Hodgkin’s disease Peripheral neuropathy is dose-limiting

Adenosine analogue Hairy cell leukemia, MS cladribine Adenosine analogue Hairy cell leukemia, MS

Cross-links guanines Genitourinary & lung cancer carboplatin Cross-links guanines Genitourinary & lung cancer

Inhibits microtubule depolymerization Ovarian and NSC lung cancer paclitaxel Inhibits microtubule depolymerization Ovarian and NSC lung cancer

topotecan Topoisomerase I inhibitor Small cell lung cancer and cervical carcinoma Beware life-threatening diarrhea

cisplatin Cross-links guanines Genitourinary & lung cancer Watch nephrotoxicity; co-admin amifostine

Inhibits microtubule depolymerization Breast and gastric cancer docetaxel Inhibits microtubule depolymerization Breast and gastric cancer