1Scientific Advisory Board meeting | 31 maart 2011 Milan WP2: Data organisation and electronic platform Polly Boon

Scientific Advisory Board meeting | 31 maart 2011 Milan 2 Contents WP2 tasks MCRA WP2 state of the art Plans for the future

Scientific Advisory Board meeting | 31 maart 2011 Milan 3 WP2 Title: Cumulative dietary exposure and hazard assessment Partners involved: –CZ: National Institute of Public Health –NL: National Institute for Public Health and the Environment –IT: University of Milan / National Research Institute for Food and Nutrition –SE: National Food Administration –UK: Chemicals Regulation Directorate Partners outside project: –F: ANSES –DK: DTU

Scientific Advisory Board meeting | 31 maart 2011 Milan 4 WP2: Tasks (1) Organisation of input data –National food consumption data –National pesticide residue concentration data OPs, triazoles, synthetic pyrethroids, chlorpyrifos National monitoring programmes –Processing –Variability + unit weight –Relative Potency Factors –Harmonisation of the data: Coding input data Conversion to RAC ingredient National recipes / conversion factors Pooling data National data available for cumulative exposure modelling

Scientific Advisory Board meeting | 31 maart 2011 Milan 5 BMD modelling –Organisation of the tox data relevant for identified chemical groups OPs, triazoles, synthethic pyrethroids Data needed from toxicology (animal) studies: For quantal data: doses used, no. of responding animals per group, total no. of animals per group For continuous data: doses, mean response per dose group, SD in each group, and no. of animals per group. DARs, EFSA, JMPR, EPA, other sources (?) Derivation RPFs based on the same toxicological endpoint, using the same effect size WP2: Tasks (2)

Scientific Advisory Board meeting | 31 maart 2011 Milan 6 Use of developed cumulative exposure model –Case studies: OPs, triazoles, synthetic pyrethroids Chlorpyrifos (biomarker) –Based on EFSA guideline PPR, 4 exposure scenarios –Based on current version (7.0) of MCRA –RPFs: Derived from BMD modelling WP2: Tasks (3)

Scientific Advisory Board meeting | 31 maart 2011 Milan 7 Internet based model (mcra.rivm.nl) Modelling of dietary exposure / intake of food chemicals (both adverse and beneficiary) Human population –Including subgroups (age, sex, diet, etc) Acute and chronic exposure –Acute: Monte Carlo sampling –Chronic: Statistical modelling MCRA: Characteristics (1)

Scientific Advisory Board meeting | 31 maart 2011 Milan 8 MCRA: Characteristics (2) Input: –Food consumption data (daily consumption patterns of individuals) –Concentration data (e.g. monitoring programmes, field trial, MRL) Concentrations assigned to samples < LOR (% crop treated) –Processing factors (fixed, distribution) –Variability factors, unit weights –Empirical or distributions –Conversion model Link between foods consumed and commodities analysed Inclusion of mixed/prepared foods like pizza, bread

Scientific Advisory Board meeting | 31 maart 2011 Milan 9 MCRA: Characteristics (3) Uncertainty analyses: bootstrapping –Concentration –Consumption –Processing factors Cofactor / covariable analysis (chronic modelling) –Sex / age Scenario / sensitivity analyses

Scientific Advisory Board meeting | 31 maart 2011 Milan 10 MCRA: How does it work? Calculation consists of four steps Specify input data Specify model Set and run model View output I II II I IVIV

Scientific Advisory Board meeting | 31 maart 2011 Milan 11 MCRA: Selection of input data (1) I

Scientific Advisory Board meeting | 31 maart 2011 Milan 12 MCRA: Selection of input data (2) I A B

Scientific Advisory Board meeting | 31 maart 2011 Milan 13 MCRA: Specify model (1) II

Scientific Advisory Board meeting | 31 maart 2011 Milan 14 MCRA: Specify model (2) II

Scientific Advisory Board meeting | 31 maart 2011 Milan 15 MCRA: Set and run (1) II I

Scientific Advisory Board meeting | 31 maart 2011 Milan 16 MCRA: Set and run (2) II I

Scientific Advisory Board meeting | 31 maart 2011 Milan 17 MCRA: View output (1) IVIV

Scientific Advisory Board meeting | 31 maart 2011 Milan 18 MCRA: View output (2) IVIV

Scientific Advisory Board meeting | 31 maart 2011 Milan 19 MCRA: View output (3) IVIV

Scientific Advisory Board meeting | 31 maart 2011 Milan 20 MCRA: View output (4) Total distribution Upper 5 % (> 0.34 ug/kg bw/d) IVIV

Scientific Advisory Board meeting | 31 maart 2011 Milan 21 WP2: State of the art (1) National food consumption have been organised: –National food codes –FoodEX1 codes National concentration data have been organised: –Captan and triazoles –RACs: CODEX codes (SAFE FOODS) Link based on Dutch RAC conversion model Four exposure scenarios of EFSA: captan, using MCRA

Scientific Advisory Board meeting | 31 maart 2011 Milan 22 WP2: State of the art (2) BMD modelling Inventory of triazole toxicity data from DARs, JMPR and EFSA, resulting in first dose response analysis using PROAST OPs data: SAFE FOODS Synthetic pyrethroids: ?

Scientific Advisory Board meeting | 31 maart 2011 Milan 23 WP2: Immediate plans for the future Cumulative exposure to triazoles according to four scenarios of EFSA Inclusion of F and DK in the platform Conversion of national foods to RACs based on national recipe data and conversion factors Harmonisation coding of RACs analysed according to EU pesticide regulation Harmonisation coding foods consumed using FoodEx codes BMD modelling: Further research triazoles BMD modelling OPs Synthetic pyrethroids

24Scientific Advisory Board meeting | 31 maart 2011 Milan acropolis-eu.com