Chapter 8: An Introduction to Metabolism

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Chapter 8: An introduction to Metabolism
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Presentation transcript:

Chapter 8: An Introduction to Metabolism

Energy: Kinetic energy: Potential energy: Energy is the capacity to cause change Energy exists in various forms, some of which can perform work Kinetic energy is energy associated with motion Heat (thermal energy) is kinetic energy associated with random movement of atoms or molecules Potential energy is energy that matter possesses because of its location or structure Chemical energy is potential energy available for release in a chemical reaction Energy can be converted from one form to another

Fig. 8-2 A diver has more potential energy on the platform than in the water. Diving converts potential energy to kinetic energy. Figure 8.2 Transformations between potential and kinetic energy Climbing up converts the kinetic energy of muscle movement to potential energy. A diver has less potential energy in the water than on the platform.

The First Law of Thermodynamics According to the first law of thermodynamics, the energy of the universe is constant: – Energy can be transferred and transformed, but it cannot be created or destroyed The first law is also called the principle of conservation of energy Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

The Second Law of Thermodynamics During every energy transfer or transformation, some energy is unusable, and is often lost as heat According to the second law of thermodynamics: – Every energy transfer or transformation increases the entropy (disorder) of the universe Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Free-Energy Change, G Free energy is a measure of a system’s instability, its tendency to change to a more stable state A living system’s free energy is energy that can do work when temperature and pressure are uniform, as in a living cell The change in free energy (∆G) during a process is related to the change in enthalpy, or change in total energy (∆H), change in entropy (∆S), and temperature in Kelvin (T): ∆G = ∆H – T∆S Only processes with a negative ∆G are spontaneous Spontaneous processes can be harnessed to perform work Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Fig. 8-5 More free energy (higher G) Less stable Greater work capacity In a spontaneous change The free energy of the system decreases (∆G < 0) The system becomes more stable The released free energy can be harnessed to do work Less free energy (lower G) More stable Less work capacity Figure 8.5 The relationship of free energy to stability, work capacity, and spontaneous change (a) Gravitational motion (b) Diffusion (c) Chemical reaction

Exergonic and Endergonic Reactions in Metabolism An exergonic reaction: An endergonic reaction: An exergonic reaction proceeds with a net release of free energy and is spontaneous An endergonic reaction absorbs free energy from its surroundings and is nonspontaneous Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Progress of the reaction Fig. 8-6 Reactants Amount of energy released (∆G < 0) Energy Free energy Products Progress of the reaction (a) Exergonic reaction: energy released Products Figure 8.6 Free energy changes (ΔG) in exergonic and endergonic reactions Amount of energy required (∆G > 0) Energy Free energy Reactants Progress of the reaction (b) Endergonic reaction: energy required

Figure 8.7 Equilibrium and work in isolated and open systems (a) An isolated hydroelectric system (b) An open hydroelectric system ∆G < 0 Figure 8.7 Equilibrium and work in isolated and open systems ∆G < 0 ∆G < 0 ∆G < 0 (c) A multistep open hydroelectric system

The Structure and Hydrolysis of ATP ATP (adenosine triphosphate) is the cell’s energy shuttle ATP is composed of ribose (a sugar), adenine (a nitrogenous base), and three phosphate groups Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Energy is released from ATP when the terminal phosphate bond is broken The bonds between the phosphate groups of ATP’s tail can be broken by hydrolysis Energy is released from ATP when the terminal phosphate bond is broken This release of energy comes from the chemical change to a state of lower free energy, not from the phosphate bonds themselves Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

H2O P P P Adenosine triphosphate (ATP) P + P P + Energy Fig. 8-9 P P P Adenosine triphosphate (ATP) H2O Figure 8.9 The hydrolysis of ATP P + P P + Energy i Inorganic phosphate Adenosine diphosphate (ADP)

Membrane protein Solute Solute transported Vesicle Cytoskeletal track Fig. 8-11 Membrane protein P P i Solute Solute transported (a) Transport work: ATP phosphorylates transport proteins ADP ATP + P i Vesicle Cytoskeletal track Figure 8.11 How ATP drives transport and mechanical work ATP Motor protein Protein moved (b) Mechanical work: ATP binds noncovalently to motor proteins, then is hydrolyzed

The Regeneration of ATP ATP is a renewable resource that is regenerated by addition of a phosphate group to adenosine diphosphate (ADP) The energy to phosphorylate ADP comes from catabolic reactions in the cell The chemical potential energy temporarily stored in ATP drives most cellular work Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

+ H2O Energy for cellular work (endergonic, energy-consuming Fig. 8-12 ATP + H2O Energy from catabolism (exergonic, energy-releasing processes) Energy for cellular work (endergonic, energy-consuming processes) Figure 8.12 The ATP cycle ADP + P i