Teledyne Isco Confidential The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

CombiFlash Rf 150 Features Flow rate up to 100 mL/min Pressures up to 150 psi (10.3 bar) Binary Gradient Two solvent selectivity Uses standard Rf racks Ceramic piston with no check valves for maintenance free operation Low pressure mixing Gradient accuracy typically 2% of full scale Variable UV or UV-Vis detection options Uses PeakTrak® control software November Software release will add Spectral capabilities to Rf 150 Teledyne Isco Confidential

Optimized for Reversed Phase Purifications Reversed phase purifications often operate at pressures between 75 psi and 100 psi Designed to run at maximum flow rate up to 150 psi Available with either a variable UV or UV-Vis detector Driven by PeakTrak® Teledyne Isco Confidential

Teledyne Isco Confidential Market Focus for Rf 150 Aimed at Academic Market Heavy discounting is needed to win business May not use RediSep® Rf columns Infrequent usage accounts Financially underfunded accounts Teledyne Isco Confidential

Teledyne Isco Confidential Rf 150 Product Promotions Direct Mail Piece to Academic accounts ACS Members who are Post Doctorial Fellows (5,000) Email blast to University names from R&D List Email blast to University names in Tisco List Teledyne Isco Confidential

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Teledyne Isco Confidential Rf 200 versus Rf 150 Rf 200 Rf 150 RFID rack identification RFID rack detection RFID column detection Supports column plan External detector port Solvent level sensing Injection valve Air purge Four solvents to select from Higher pressure and flow rate limits No rack identification No rack detection No external detector DOES NOT SUPPORT COLUMN PLAN No air purge Two solvents to choose from Lower pressure and flow rate No level sensing No injection valve Teledyne Isco Confidential

Competition Biotage Isolera Prime   CombiFlash Rf 150 Isolera Prime Pumping System Ceramic no-check valve pump Constant Volume Electric Pump Flow Range 10 - 100 mL/min 5 - 100 mL/min Pressure Limit 150 psi (10.3 bar) 145 psi (10 bar) Detection Variable UV 200 - 360 nm standard Variable UV-Vis 200 - 780 nm option Fxed UV 254nm standard Variable UV 200 -0400 nm option Number of Solvents Two, binary gradient Programmable Gradients Linear, step, isocratic Gradient Accuracy Typically <2% Not Stated  Sample Injection Direct User Interface 10.5" touchscreen 10.4" touchscreen Software PeakTrak Proprietary Fraction Collector Internal Dimensions 24" H x 14.1" W x 17" D 23.5" H x 14" W x 19.6" D Column Sizes 4 to 330 Gram Not Stated   Weight 66 lbs. Certifications CE CE, cTUVus Biotage US List Price of $17,500 Teledyne Isco Confidential

Competition - Agela Cheetah   CombiFlash Rf 150 Agela Cheetah MP 100 Pumping System Valveless ceramic metering pump Flow Range 10 - 100 mL/min 1 - 100 mL/min Pressure Limit 150 psi (10.3 bar) 100 psi Detection Variable UV 200 - 360 nm standard Variable UV-Vis 200 - 780 nm option Variable UV 200 - 400 nm standard Variable UV-Vis 200 - 800 nm option Number of Solvents Two, binary gradient Two, binary gradient standard Quaternary gradient option Programmable Gradients Linear, step, isocratic Gradient Accuracy Typically <2%  Not Stated Sample Injection Direct Direct Injection valve option User Interface 10.5" touchscreen 12.1" touchscreen Software PeakTrak Proprietary Fraction Collector Internal Dimensions 24" H x 14.1" W x 17" D   Not Stated Column Sizes 4 to 330 Gram Weight Certifications CE Agela US List Price Unknown – Sold through VWR Teledyne Isco Confidential

Competition – Lisure Science   CombiFlash Rf 150 Lisure Science EZ Purifer Pumping System Valveless ceramic metering pump Flow Range 10 - 100 mL/min 1 - 100 mL/min Pressure Limit 150 psi (10.3 bar) 100 psi (7 bar) Detection Variable UV 200 - 360 nm standard Variable UV-Vis 200 - 780 nm option Variable UV-Vis 200 - 800 nm Number of Solvents Two, binary gradient Programmable Gradients Linear, step, isocratic Gradient Accuracy Typically <2% +/-3% linear gradient Sample Injection Direct User Interface 10.5" touchscreen PC Software PeakTrak Windows Fraction Collector Internal Dimensions 24" H x 14.1" W x 17" D Not Stated Column Sizes 4 to 330 Gram Weight Certifications CE  Not Stated  Lisure does not sell outside of India and China Teledyne Isco Confidential

Competition - Yamazen Yamazen US List Price $21,200   CombiFlash Rf 150 Yamazen AI-580S Pumping System Valveless ceramic metering pump Not Stated  Flow Range 10 - 100 mL/min 0 - 80 mL/min Pressure Limit 150 psi (10.3 bar) 145 psi Detection Variable UV 200 - 360 nm standard Variable UV-Vis 200 - 780 nm option Fixed UV 254 nm standard Variable UV 190 - 380 nm Variable UV-Vis 190 - 600 nm option Number of Solvents Two, binary gradient Programmable Gradients Linear, step, isocratic Gradient Accuracy Typically <2% Sample Injection Direct User Interface 10.5" touchscreen Touch screen PC Software PeakTrak Windows Fraction Collector Internal Dimensions 24" H x 14.1" W x 17" D 30.7" H x 19.7" W x 17.7" D Column Sizes 4 to 330 Gram Weight Certifications CE JIS, CE Yamazen US List Price $21,200 Teledyne Isco Confidential

Teledyne Isco Confidential Pricing 68-5230-014 UV $24,004 68-5230-015 UV-Vis $25,004 Teledyne Isco Confidential

Key Markets Pharmaceutical Drug Discovery Agricultural Chemistry Petrochemicals Natural Products Foods and Flavors Teledyne Isco Confidential