What is Spinal Cord Injury?What is Spinal Cord Injury?  Spinal cord: bundle of nerves which run through the spine  Damages/injuries cause: loss of sensory.

Slides:

Advertisements

Similar presentations

Miami CTSI--Culturalized Health Sciences for a Healthier South Florida! Clinical & Translational Science Institutes The U.S.A. launches an initiative to.

Advertisements

Multiple Sclerosis By Rachel Utnage and Anne Creech 1 st Period-Anatomy and Physiology (Honors) April 30 th, 2013.

Overview of the Nervous System

Louis Carney III BME 281 October 8 th,  About 300,000 Americans a year suffer damage to peripheral and central nerves.  Nerves damaged in the.

Overview The Nervous System. The nervous system of the human is the most highly organized system of the body. The overall function of the nervous system.

1 BrainStorm is a leading developer of stem cell technologies to provide treatments for currently incurable neurodegenerative.

Notes pg 71 Title: Nervous System How does information get from one place in your body to another?

Journal Club Alcohol, Other Drugs, and Health: Current Evidence May-June 2007.

Multiple Sclerosis Definition: Multiple sclerosis (MS) is a disease of the central nervous system (CNS); it damages the protective coating around the.

Spinal Cord Injury/Repair

Functional Electrical Stimulation ZAIN SULTAN EE NAEEM HUSSAIN EE

Nerve Cell Regeneration Heather Wilson and Alicia DiCola.

Spinal Cord Injuries.  There are an estimated 10,000 to 12,000 spinal cord injuries every year in the United States.  The cost of managing the care.

What is the spinal cord? The spinal cord is a bundle of nerve fibers and associated tissue that is enclosed in the spine. These fibers connect nearly.

By: Nathan & James. Our Patient (Totally breaking HIPPA) Name: Helen Weezy F Baby Age: 28 Symptoms: Strange pricks in her hands and feet, fatigue, impaired.

Divisions of the Nervous System There are 2 main divisions of the nervous system. – 1. Central Nervous System – 2. Peripheral Nervous System.

Mrs. Wharton’s Science Class. Vocabulary Central nervous system- consists of brain and spinal cord Peripheral nervous system- consists of all the nerves.

Nervous System Human Body Systems Project Caroline Crinion.

Nervous System By: Vivian Chang Danielle LaCroix.

Nervous System Is the body’s control center. Carries messages to and from the brain. Carries messages to and from the brain. Controls senses, thoughts,

ANATOMY NERVOUS SYSTEM OVERVIEW. Nervous System  The nervous system of the human is the most highly organized system of the body.  The overall function.

Worldwide, an estimated 2.5 million people live with spinal cord injury (SCI), with more than 130,000 new injuries reported each year. SCI has a significant.

Biotechnology Research Project by Anna Dong, Soojin Jeong, Reina Ooka -Stem Cells-

New Hope for Hurt Neurons Is there recovery after damage to the spinal cord or brain? Can stem cells be used to reconstruct broken pathways? A few years.

SNC 2D. The organ system that is made up of the brain, spinal cord, and the peripheral nerves System that senses the environment and coordinates appropriate.

The Ethics of Stem Cell Research Presented by Corey Gomes Bme 181 April 15, 2013.

DO NOW : List as many functions of the brain as you can. How do you think the brain coordinates all the different activities? Objectives: 1.Describe the.

Your Nervous System The nervous system is the body’s control and communication center of the body. It’s job is to send and receive messages. Your nervous.

The Nervous System. Nervous System Central Nervous System (CNS) – consists of the brain and spinal cord ONLY Peripheral Nervous System (PNS) – consists.

By: Jean Collado. About The Spinal Cord  The spinal cord is about 18 inches long and extends from the base of the brain, down the middle of the back,

Divisions of the Nervous System Describe the structures and functions of the CNS and PNS Explain what a reflex is ID 2 ways in which the NS can be injured.

Nervous System Overview. Divided into Two Parts: Central (CNS) Peripheral (PNS)

SPINAL CORD INJURY What is the spinal cord?

The e-Dura: The New Flexible Spinal Implant That Will Revolutionize Spinal Cord Injury Treatment The Spinal Cord and Effects of Spinal Cord Injuries (SCI)

Nervous System. What is the main function of the nervous system? to receive stimuli from inside and outside the body to interpret the stimuli initiate.

The Nervous System. Functions of the Nervous System 1.Control center for all body activities 2.Responds and adapts to changes that occur both inside and.

Project NEUWalk George Halkidis BME 181 Pres. #1.

MULTIPLE SCLEROSIS BY EMILY HOWARD. Multiple Sclerosis (MS) Multiple sclerosis (or MS) is a chronic, often disabling disease of the immune system that.

Nervous System. What does the nervous system do? The nervous system picks up messages from in and out of the body and turns them into signals that coordinate.

Spinal cord injuries: Paraplegia: paralysis of both lower limbs Quadriplegia: paralysis of all 4 limbs  Complete transection: loss of all sensations and.

Bell ringer Where can you find a sensory neuron? Interneuron? Motor neuron?

 What are the three types of muscle?  Which two muscle types are involuntary?  Which is voluntary?

Multiple Sclerosis. What is MS? This is a chronic and often disabling disease in which the body’s immune system (t-cells) attacks the central nervous.

 Central Nervous System (CNS)  Peripheral Nervous System (PNS)

Genetic Engineering Stem Cells by Shivi Agarwal. Itinerary followed for Padlet Sept 21 st – Read a journal and wrote its summary Sept 24 th - Posted questionnaire.

Register for Stem cell Treatment in India : The Unique Healthcare Centre

CENTRAL NERVOUS SYSTEM

The Nervous System By: Skylar and Morgan.

The Nervous System.

Olfactory Ensheathing Cells and CNS Regeneration

Nervous System Overview.

Nervous System Overview.

Descending pathways.

Nat. Rev. Neurol. doi: /nrneurol

Incidence, Prevalence, Costs, and Impact on Disability of Common Conditions Requiring Rehabilitation in the United States: Stroke, Spinal Cord Injury,

Chapter 17-1: The Nervous System

Figure 3 Proportion of patients for whom NEDA

Figure 5 Number of AHSCT procedures for

Marie C. Harrisingh, Charles ffrench-Constant Cell Stem Cell

The Center of the Spinal Cord May Be Central to Its Repair

Overview of CNS Structure and Function

Brainiac! What is the function of the nervous system?

Figure 2 Primary and secondary outcomes reported in multiple sclerosis (MS) disease-modifying therapy (DMT) clinical trials Primary and secondary outcomes.

Olfactory Ensheathing Cells and CNS Regeneration

Unit 2 Notes: Neurons & Nervous System Organization

Nat. Rev. Neurol. doi: /nrneurol

Saltatory Conduction.

Disease of the Central Nervous System By Eric Nauman

Building Bridges for Spinal Cord Repair

Quadriplegia Tj Bognot R4.

Presentation transcript:

What is Spinal Cord Injury?What is Spinal Cord Injury?  Spinal cord: bundle of nerves which run through the spine  Damages/injuries cause: loss of sensory input & voluntary/involuntary functions  Two Types of spinal cord injuries:  Traumatic spinal cord injury  Non-traumatic spinal cord injury

MedicaLook.com, 2013

ChristopherReeve.org

Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double- blinded trial in a canine translational model Nicolas Granger, Helen Blamires, Robin J. M. Franklin and Nick D. Jeffery  Hypothesis: If olfactory mucosal cells (OMC) are transplanted into the spine of a canine with spinal cord injury, then there should be improved fore-hind limb coordination/movement  Purpose: To use olfactory mucosal cells as a prospective therapy for spinal cord injuries  Model: Dogs with spinal cord injuries

Granger et al., 2012

Measured Variables Dogsforlifex.blogspot.com

Cell harvest and culture Multiple-sclerosis-research.blogspot.comGranger et al., 2012

Granger et al, 2012

Results  Significant data from primary measures, but not from secondary measures  Subjects who received mucosal cell transplant regained some fore-hind coordination/movement  Coordination and movement ≠ restoration of brain control  Coordination may be due to enhanced communication across damaged region of spinal cord  Implies long tract axon improvement, however data suggests otherwise

Hopes for Humans?  Humans with spinal cord injury want the recovery of: 1.Arm function 2.Bladder function 3.Sexual function  Olfactory mucosal cell transplant would result in some improvement  Should not be the sole treatment  Transplantation is not the safest for humans

Past Studies Deshpande et al, 2006

References  A.D.A.M inc: Spinal cord & Brain (image):  Deshpande, D., Kim, Y., Martinez, T., Carmen, J., Dike, S., Shats, I., & Rubin, L. (2006). Recovery from Paralysis in Adult Rats Using Embryonic Stem Cells. Ann Neurol, 60,  DogsForLife: A Dog’s Brain (image)  Farlex. “Double-blind study”. Mosby’s Medical Dictionary, 8th Edition Elsevier.  Farry, A., Baxter, D. (2012), The incidence and prevalence of spinal cord injury in Canada.: overview and estimates based on current evidence. Rick Hansen Institute & Urban Futures.  Granger N., Blamires H., Franklin R.J., Jeffery N.D. (2012). Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model. Brain, 11: doi: /brain/aws268.  Jefferey, N.D., Lakatos, A., and Franklin, R.J.M. (2005). Autologous Olfactory Glial Cell Transplantation is Reliable and Safe in Naturally Occurring Canine Spinal Cord Injury. Journal of Neurotrama, 22:  Multiple Sclerosis Research: Olfactory Tissue Diagram (image)