BBS3027 2000: Infectious Diseases Dr Garwin Sing

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Presentation transcript:

BBS : Infectious Diseases Dr Garwin Sing

Gut Mucosa

Mucosal Epithelium

Epithelial Barriers to Microbial Infection: Physical Epithelial cells joined by tight junctions Exfoliation of surface cells Mucous flow by ciliated epithelia (respiratory tract)

Epithelial Barriers to Microbial Infection: Chemical Enzymes: Lysozyme (tears, saliva, sweat) Pepsin (stomach) pH:Fatty Acids/amino acids (skin) Gastric acids (stomach) Antimicrobial:Transferrin (mucus)

Epithelial Barriers to Microbial Infection: Competition Gut Flora

Protection from Infectious Agents Innate ImmunityFever, interferon, neutrophils, macrophages, NK cells Adaptive ImmunityB cells, T cells

Congenital Infections

Viruses Bacteria Fungi Parasites Anatomy Physiology Immunity Commensals

Sources of Infection: Exogenous InhalationCommon cold, flu, Legionnaire’s Disease, Coccidioidomycosis IngestionTyphoid fever, tapeworm, cryptosporidium, Hepatitis A STDGonorrhea, HIV WoundTetanus, Rabies Insect BiteMalaria, Yellow Fever, Dengue

Sources of Infection: Endogenous Gute.g E coli Skine.g. staphylococcus Tonsils Throat e.g streptococcus Bloode.g. EBV Lungse.g Candida, CMV, streptococcus

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