G Linked Receptors (Continued…….). Serine/Threonine Protein Phosphatases Rapidly Reverse the Effects of A-Kinase.

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Presentation transcript:

G Linked Receptors (Continued…….)

Serine/Threonine Protein Phosphatases Rapidly Reverse the Effects of A-Kinase

To Use Ca2+ as an Intracellular Signal, Cells Must Keep Resting Cytosolic Ca2+ Levels Low

Ca2+ Functions as a Ubiquitous Intracellular Messenger

Some G-Protein-linked Receptors Activate the Inositol Phospholipid Signaling Pathway by Activating Phospholipase C-b

Inositol Trisphosphate (IP3) Couples Receptor Activation to Ca2+ Release from the ER

Diacylglycerol Activates Protein Kinase C (C-Kinase)

Calmodulin Is a Ubiquitous Intracellular Ca2+ Receptor

Ca2+/Calmodulin-dependent Protein Kinases (CaM-Kinases) Mediate Most of the Actions of Ca2+ in Animal Cells

How do the Cyclic AMP and Ca2+ Pathways Interact?????

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