Side effects of anti-TB medications HREZ

Isoniazid Isoniazid-induced hepatitis-most common major toxic effect Peripheral neuropathy CNS toxicity-memory loss, psychosis,seizures Fever and skin rashes Drug-induced SLE Hematologic abnormalities Provocation of pyridoxine deficiency anemia Tinnitus Gastrointestinal discomfort Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 773

Rifampicin Orange urine, sweat and tears Rashes Thrombocytopenia Nephritis Light-chain proteinuria Flu-like sydrome(fever, chills, myalgia, anemia and thrombocytopenia) Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774

Ethambutol Retrobulbar neuritis most common serious adverse event Loss of visual acuity and red-green color blindness Hypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis) Fever and lymphadenopathy Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774 http://www.drugs.com/sfx/ethambutol-side-effects.html

Pyrazinamide Hepatotoxicity-major adverse effect Nausea Vomiting Fever hyperuricemia Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 775

*Streptomycin Vertigo and hearing loss nausea, vomiting paresthesia of face rash fever Urticaria angioneurotic edema eosinophilia Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 775 http://www.drugs.com/sfx/streptomycin-side-effects.html