AVR Distribution by Age, Cusp, and CAD Data 932 consecutive AVR patients 1993–2004 Roberts, Circulation. 2005; 111:920–925.

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AVR Distribution by Age, Cusp, and CAD Data 932 consecutive AVR patients 1993–2004 Roberts, Circulation. 2005; 111:920–925

Cusp Type and/or CAD Prevalence in AVR pts. over age 70 AVBG Transcatheter Valve Bicuspid w/o CAD20%+ Contraindicated * Bicuspid w/CAD20%+ Contraindicated * Tricuspid w/o CAD21%++ Tricuspid w/ CAD39%+ Contraindicated * Alternative Therapies by Cusp Type and CAD Edwards LifeScience PARTNER Trial protocol European Association of Cardio-Thoracic Surgeons guidelines European Society of Cardiology guidelines * Patients with Bicuspids or Untreated Significant CAD are contraindicated for transcather valve implantaion Future CAD Intervention Bicuspid

Will Transcatheter procedures be applicable to broad market segment? AttributeNo CADCAD Tricuspid 21%39% Bicuspid 20% Key PARTNER Trial Exclusion Criteria: Aortic valve is a congenital unicuspid or bicuspid valve; or is non-calcified Untreated clinically significant coronary artery disease requiring revascularization AVR Patients Age 70+ Data 932 consecutive AVR patients 1993–2004 Roberts, Circulation. 2005; 111:920–925