8636 bp 18s TG (10 nM) 0 1 3 6 12 24 TG (100 nM) 0 1 3 6 12 24 (hr) Supplemental Fig. 1 Supplemental Fig. 2 CHOP GRP78 GRP94 CHOP GRP78 GRP94 homocysteine.

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8636 bp 18s TG (10 nM) TG (100 nM) (hr) Supplemental Fig. 1 Supplemental Fig. 2 CHOP GRP78 GRP94 CHOP GRP78 GRP94 homocysteine (mM) palmitate (mM) homocysteine (mM) palmitate (mM) Supplemental Fig TM (ng/ml) CHOP GRP78 GRP94 TM (ng/ml) s 8636 bp 18s 8636 bp * mtDNA/nDNA (arbitrary unit) mtDNA/nDNA (arbitrary unit) * 18s 8636 bp mtDNA/nDNA (arbitrary unit) *

HepG2 cell NRF-1 TFAM 18s HO-1 PGC1α CHOP GRP78 XBP-1 TG (10nM ) A B 18s TG (10nM ) NRF-1 TFAM 18s HO-1 PGC1α TG ( nM) XBP-1 18s TG ( nM) U937 cells Supplemental Fig. 4 CHOP GRP78

WT TG (nM) bp 18s PERK -/- B 8636 bp 18s TG (100 nM) ZnPP (  M) A Supplemental Fig. 5 TG (100 nM) Hb (  g) A 8636 bp 18s Supplemental Fig. 6