The Way Forward in the UK

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Presentation transcript:

The Way Forward in the UK TrueAllele® Workshop April, 2013 Leicestershire, United Kingdom Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA Cybergenetics © 2003-2013 Cybergenetics © 2007-2012

TrueAllele mixture validation: Virginia case study Perlin MW et al. Virginia TrueAllele® vaildation study: casework comparison. American Academy of Forensic Sciences 65th Annual Meeting, 2013; Washington, DC. TrueAllele mixture validation: Virginia case study Establish the reliability of TrueAllele mixture interpretation Mark W Perlin, PhD, MD, PhD Kiersten Dormer, MS and Jennifer Hornyak, MS Cybergenetics, Pittsburgh, PA Lisa Schiermeier-Wood, MS and Susan Greenspoon, PhD Department of Forensic Science, Richmond, VA Cybergenetics © 2007-2012

Case composition • 72 criminal cases • 92 evidence items • 111 genotype comparisons Criminal offense • 18 homicide • 12 robbery • 6 sexual assault • 20 weapon

DNA mixture distribution

Human review information 2.26 HR1 6.70 Nothing reported 25

2010 guidelines: modified human review information 2.26 56 HR1 HR2 1.75 2.12 6.70 Nothing reported 25

TrueAllele reinterpretation Virginia reevaluates DNA evidence in 375 cases July 16, 2011 “Mixture cases are their own little nightmare,” says William Vosburgh, director of the D.C. police’s crime lab. “It gets really tricky in a hurry.” “If you show 10 colleagues a mixture, you will probably end up with 10 different answers” Dr. Peter Gill, Human Identification E-Symposium, 2005

TrueAllele sensitivity 2.26 56 HR1 HR2 TrueAllele 1.75 5.52 2.12 6.70 10.93 Nothing reported 25 9

TrueAllele specificity True exclusions, without false inclusions – 19.69

TrueAllele reproducibility Concordance in two independent computer runs standard deviation (within-group) 0.305 log(LR2) log(LR1)

TrueAllele computer genotyping is more effective than human review Validation results TrueAllele® Casework DNA mixture interpretation is: A reliable method • sensitive • specific • reproducible TrueAllele computer genotyping is more effective than human review

TrueAllele Virginia outcomes 144 cases analyzed 72 case reports – 10 trials City Court Charge Sentence Richmond Federal Weapon 50 years Alexandria Bank robbery 90 years Quantico Military Rape 3 years Chesapeake State Robbery 26 years Arlington Molestation 22 years Homicide 35 years Fairfax Abduction 33 years Norfolk 8 years Charlottesville 15 years Hampton Home invasion 5 years

TrueAllele in Virginia • Department of Forensic Science has their own TrueAllele system • Training, validation, approvals • Services centralized in Richmond • DFS will provide DNA mixture statistics and court testimony

Perlin MW, Belrose JL, Duceman BW Perlin MW, Belrose JL, Duceman BW. New York State TrueAllele® Casework validation study. Journal of Forensic Sciences. 2013;58(6):in press. TrueAllele in New York

TrueAllele in the United States Casework system Interpretation services

TrueAllele in the United Kingdom 2000: FSS & TrueAllele Databank • first fully automated DNA expert system • for reference samples only • faster: eliminated 350,000 item backlog • better: eliminated human error of 0.05% • cheaper: eliminated 100 jobs 2010: PSNI & TrueAllele Casework • match stats for complex DNA evidence • 3-4 person DNA mixtures • low-template & degraded DNA

DNA Pathway Restored Lab Infer Evidence item Evidence data Evidence genotype 10, 10 @ 30% 10, 12 @ 50% 10, 14 @ 20% + 7 10 12 14 Compare Known genotype 10, 12

TrueAllele Applications • murder • rape • gangs • terror • IEDs • cold cases • DVI • property crime • prevention

Real Information, Real Time Evidence Genotype database Infer & Upload Crime scene +

Real Information, Real Time Evidence Reference Genotype database Genotype database Infer & Upload Crime scene Criminals +

Real Information, Real Time Evidence Reference Genotype database Genotype database Match & Report Infer & Upload Crime scene Criminals +

Continuous Crime Scene Mapping Suspects: S1, S2, S3, S4, S5 Market • hat 1 • hat 2 • overalls • shirt Food mart • gun • hat Jewelry • counter • safe Convenience • keys • tape Hardware • safe • phone

TrueAllele Deployment • in the cloud (Cybergenetics service) • in your station or laboratory (Cybergenetics product)

Police Empowerment • TrueAllele-led DNA investigation • solve challenging DNA evidence • train TrueAllele police personnel • accurate DNA interpretation • faster turnaround • less human effort • consistent answers • preserve identification information • DNA evidence within cases • automated investigative database

Getting Started http://www.cybgen.com/support

Moving Forward • Send one case (no cost) • Discuss match results • Assess TrueAllele value • Identify additional cases • Determine business case • Rent or buy technology • Training and support perlin@cybgen.com