Erik van Mulligen Marco Roos Scott Marshall Maarten Hekkelmans Martijn Schuemie Ivo Fokkema Marc van Driel Barend Mons Nigam Shah Andrew Gibson Gerard Meijssen Yaron Koren Marc Weeber Christine Chicester Daniel Kinzler Ravi Kalaputapu Acknowledgements Antoine van Kampen Ruben Kok Gert Jan van Ommen Johan den Dunnen Bill Melton The ‘Virtual Tech Team’ Albert Mons Jan Velterop Jacintha van Beemen Geoffrey Bilder Mark Musen Carole Goble Frank van Harmelen Financial support Logistics and advise

TokenObject Concept ‘cancer’ Malignant Neoplasms Krebskrankheit Etc C0-265 Unique ID

Concepts (with Unique Concept Identifiers – CIDs) Digital Objects (with Digital Object Identifiers – DOIs which are a form of Uniform Resource Name – URN) Uniform Resource Locators – URLs URLs not incorporating unique object or concept identifiers Triples incorporating concept identifiers (CIDs) URLs incorporating object identifiers (DOIs URNs) Objects can be digital or tangible, but this context is only about digital objects Concepts can be conceptual or tangible, but never digital – they can be represented digitally or not Unique concept identifiers are particularly important when they are represented digitally Uniform Resource Identifier – URI – is an umbrella term for URNs and URLs

Concept 1 Concept 2 Concept 3 Barend Mons ‘published’ This article (DOI) CAPN3_ ‘has pathogenicity’LGMD2A Dystrophin (Homo Sapiens) ‘interacts with’SNT3 Calpain-3 (Homo Sapiens) ‘has GO annotation’Proteosome Endopeptidase activity

Information silos MRS Index, virtual concepts Daily feed Triple Store Triple construction (unsupervised) Uniprot PubMed Nextprot CALIPHO InWebWikiProSERMO BioBanks LOVD GEOGWA Tools, RDF, OWL, OBO, Protege Community Annotation (a posteriori) Community Annotation (a posteriori) Direct feed Blogs, etc. Community Annotation (a priori) Peregrine Concept Mapping Query (expanded) Harmonized data

Limb girdle (free text ?) Under the hood:

Limb girdle staging.org/index.php/Concept: "/> (free text ?) The resulting triple: reference to annotator

-Self claim -proxy claim (JDD confirms this is JB) -CrossRef/Publisher mark -articles reviewed (Wikipedia Professional) -Unique Triples created -etc.

biobanks PLoS nature LOVD google

Proposal: Add all 93,000 (+) mutations to WikiProfessional display ‘status’ (submitter and curator) in pop up Link back to relevant ‘LOVD’ Edit in Pop Ups (including research notes Store each research note (also) in WikiProfessional Show research notes anywhere With reference to submitter Link to unique person page in wikipeople Have Wikipeople pages authorized by contributors Have CrossRef certify unique contributor ID Build tool to approve author self claims on publications On triples Enable proxy claims (co-authors) Enable publisher/CWA approval of claims Enable nano-credits for contributions Enable double check by on ‘identity theft’ Write/review Wikipedia article on each genetic disease