Omega-3 fatty acid intake effect on allergy severity MBA 555 Fall 2011 Rebecca Fan

Introduction Epidemiological research has indicated that allergy disease is triggered by the combination of both genetic and environmental factors Few studies has reported that intake of omega- 3 fatty acid could potentially reduce the blood pressure and allergy severity level Omega-3 supplementation during pregnancy and lactation could decrease the risk of childhood asthma; however the evidence was not conclusive across different studies

Introduction Serum IgE level has been recognized as the surrogate for allergy severity level measurement Variations of normal total serum IgE can range from 150 to 1,000 UI/ml; however the acceptable upper limit is usually between 150 and 300 UI/ml

Objectives Investigate the relationship between allergy severity level reduction and omega-3 intake Understand how other factors such as age, gender, height, weight, smoking and prior history of allergy could impact the effect between omega-3 intake and serum IgE level H 0 : Daily omega-3 intake(g/d) has a significant effect on serum IgE level(UI/ml), either positive or negative (two-sided test)

Data source and study population De-identified data from an allergy treatment clinical trial (on-going) 46 individuals with complete demographic information collected including: age, height, weight, gender (1=male;2=female), smoking status (1=yes;0=no), and previous allergy history (1=yes;0=no)

Analysis Software tool: WinORS Models- Ordinary Least Square (OLS) - Multiplicative model was applied to log transformed data in order to estimate the impact of % change in serum IgE level in responding to % change in omega-3 intake - Weighted Least Square (WLS)

Result - OLS White's Test for Homoscedasticity:P=

Result - OLS Normality test:P=0.987, Average VIF=1.491

Result – Multiplicative Model Elasticity parameter estimates:

Result – WLS Elasticity parameter estimates:

Conclusion and implication Elasticity of IgE level = (-0.76)*omega- 3(g/d) + (-0.245)*SEX + (0.425)*PrevHis Recommendation for nutrition intake: 10% increase in daily omega-3 intake could help to reduce serum IgE level by 8% Gender variable suggested a protective effect for female (lower IgE level compare with same condition male), possibility because women in general are more health conscious than man

References Ann Med Interne (Paris). 1985;136(5): Laurent J et al. How to define the normal level of serum IgE in adults? Acta Paediatr Sep;98(9): Furchjelm C et al. Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. BJOG 2011 Jul;118(8): doi: /j x. Klemens CM et al. The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review. Fur M Med Res Dec 7;14 Suppl 4: Wilczyska-Kwiatek A et al. Asthma, allergy, mood disorders, and nutrition. Allergy Jun;64(6): Epub 2009 Apr 7. Anandan C et al. Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis.