Genetics 210: Personalized Medicine and Genomics FOR: MDS, PHDS AND CURIOUS STUDENTS SPRING TERM. TUE 2:15 – 4:05 THUR. 2:15-4:05 GENOTYPING : $15 COPAY.

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Presentation transcript:

Genetics 210: Personalized Medicine and Genomics FOR: MDS, PHDS AND CURIOUS STUDENTS SPRING TERM. TUE 2:15 – 4:05 THUR. 2:15-4:05 GENOTYPING : $15 COPAY GENE210.STANFORD.EDU: INFO AND FAQS

Today Course overview (~30’) Informed consent (~30’) How to get genotyped (~10’) Questions (~15’)

Course Staff Course Organizers:  Stuart Kim (Dev. Bio., Genetics)  Aaron Gitler (Genetics)  Rosalind Chuang (Neurology) TAs:  Andrew Roos (Epidemiology)  Thomas Roos (Epidemiology)

Published Genome-Wide Associations

Genetics 210: Personalized Medicine and Genomics Diabetes Heart Disease Cancer Alzheimer’s, Parkinson’s/Huntington’s

Human Ancestry

Height prediction

How much Neanderthal are you? Neanderthal George Church, Harvard Geneticist

Stuart All time record

Joint Genotyping Task Force Charles Prober DeanHank Greely Law School Russ Altman GeneticsC. Braddock Med School Pat Brown Biochem.Gil Chu Biochem Mike Grecius Neur.Sean David Med. School Carlos Bustamente Gen.Harry Greenberg Dean Ralph Horwitz PsychLouanne Hudgins Epi Anne James Legal CounselJesse Karmazin Med. School Stuart Kim Dev. Bio.Mark Krasnow Biochem Phil Lavori HRPDavid Magnus Cen. BME Kelly Ormond GeneticsAlan Schatzberg Psych. Mike Snyder GeneticsAtul Butte BMI Keyan Salari Med. SchoolMildred Cho Pediatrics

Personal Genotyping Voluntary. You can use a public genome file instead of your own. Confidential – instructors will not know who opted to be genotyped. Private – Your own DNA information will not be revealed. Counseling - genetic counseling via 23andMe and medical/psychological counseling via Dr. Alan Schatzberg (Psychology, Stanford).

Introductory Projects Report on specific genetic locus. Published on SNPedia.com Class room debate on FDA legislation Unanticipated opportunities that arise as you explore your genome

Advanced Projects = (project + final) Annotate whole-genome for Stuart Kim or Aaron Gitler (adopted) Write a grant for Kaiser-Permanente GWAS (n=110,000) Analyze exome sequence data from ALS patients Write an algorithm for choosing minimal n number of people to sequence to get all sequence data in a population

Gene210 Three Manuscripts Textbook Patent Grant iPhone App in the news Chicago Medicine Magazine (story on page 18) Salon Web Magazine (9/2013) Stanford Medicine - DNA testing improves learning (8/13) San Jose Mercury News (5/2013) Time (2/2013) Nature USA Today San Francisco Chronicle Recap San Francisco Chronicle Genome Technology Stanford Press Release Nature Blogs LA Times Blog Genome Web Center for Genetics and Society Scientific American

Exploring Personal Genomics Available at Amazon.com

How to get genotyping kits 1. ATTEND THIS INFORMATION SESSION. 2. MAKE CHECK $15 TO STANFORD. 3. BRING CHECK TO KATHY FISHER IN BECKMAN B FILL OUT INFORMED CONSENT FORM 5. BRING SAMPLES BACK TO KATHY B WE WILL SHIP THE GROUP OF SAMPLES BACK TO COMPANY TUESDAY 4PM FEB RESULTS IN 6-8 WEEKS. 8. CLASS STARTS TUESDAY APRIL 1, 2012.