Chapter 9 (part 1) Lipids and Membranes. Lipids Lipids are compounds that are soluble in non-polar organic solvents, but insoluble in water. Can be hydrophobic.

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Presentation transcript:

Chapter 9 (part 1) Lipids and Membranes

Lipids Lipids are compounds that are soluble in non-polar organic solvents, but insoluble in water. Can be hydrophobic or amphipathic

Major Lipid Classes Acyl-lipids - contain fatty acid groups as main non-polar group Isoprenoids – made up of 5 carbon isoprene units

Lipid Subclasses

Function of major acyl- lipids Phospholipids – membrane components Triacylglycerols – storage fats and oils Waxes – moisture barrier Eicosanoids – signaling molecules (prostaglandin) Sphingomyelins – membrane component (impt. in mylein sheaths) Glycospingolipids – cell recognition (ABO blood group antigen)

Function of major isoprenoid lipids Steroids (sterols) – membrane component, hormones Lipid Vitamins – Vitamin A, E, K Carotenoids - photosynthetic accessory pigments Chlorophyll – major light harvesting pigment Plastoquinone/ubiquinone – lipid soluble electron carriers Essential oils – menthol

Fatty acids Amphipathic molecule Polar carboxyl group Non-polar hydrocarbon tail Diverse structures (>100 different types) Differ in chain length Differ in degree of unsaturation Differ in the position of double bonds Can contain oxygenated groups

Fatty acid nomenclature Short hand nomenclature describes total number of carbons, number of double bonds and the position of the double bond(s) in the hydrocarbon tail. C18:1  9 = oleic acid, 18 carbon fatty acid with a double bond positioned at the ninth carbon counting from and including the carboxyl carbon (between carbons 9 and 10)

Fatty acid nomenclature Omega (  ) notation – counts carbons from end of hydrocarbon chain. Omega 3 fatty acids advertised as health promoting Linoleate = 18:3  9,12,15 and 18:3  3,6,9

Common saturated fatty acids common nameIUPAC namemelting point (C o ) 12:0lauratedodeconoate44 14:0myristatetetradeconoate52 16:0palmitatehexadeconoate63 18:0stearateoctadeconoate70 20:0arachidateeicosanoate75 22:0behenatedocosanoate81 24:0lignoceratetetracosanate84

Common unsaturated fatty acids common nameIUPAC name melting point (C o ) 16:0palmitatehexadeconoate63 16:1  9 palmitoleate cis-  9 -hexadeconoate :0stearateoctadeconoate70 18:1  9 oleate cis-  9 - octadeconoate 13 18:2  9,12 linoleate cis-  9,12 - octadeconoate -9 18:3  9,12,15 linolenate cis-  9,12,15 - octadeconoate :0arachidateeicosanoate75 20:4  5,8,11,14 arachindonate cis-  5,8,11,14- eicosatetraenoate -49

Physical Properties of Fatty acids Saturated chains pack tightly and form more rigid, organized aggregates Unsaturated chains bend and pack in a less ordered way, with greater potential for motion 18:0 18:1 18:3 70 o 13 o -17 o

Melting points of fatty acids affect properties of acyl-lipids Membrane fluidity determined by temperature and the degree of fatty acid unsaturation of phospholipids Certain bacteria can modulate fatty acid unsaturation in response to temperature Difference between fats and oils Cocoa butter – perfect melt in your mouth fat made of triacylglycerol with 18:0-18:1-18:0 fatty acids Margarine is hydrogenated vegetable oil. Increase saturation of fatty acids. Introduces trans double bonds (thought to be harmful)

Unusual fatty acids can function analogously to unsaturated fatty acids

Major acyl-lipids Phospholipids – membrane components Triacylglycerols – storage fats and oils Waxes – moisture barrier Eicosanoids – signaling molecules (prostaglandin) Sphingomyelins – membrane component (impt. in mylein sheaths) Glycospingolipids – cell recognition (ABO blood group antigen)

Phospholipids Phospholipids are built on glycerol back bone. Two fatty acid groups are attached through ester linkages to carbons one and two of glycerol. Unsaturated fatty acid often attached to carbon 2 A phosphate group is attached to carbon three A polar head group is attached to the phosphate (designated as X in figure)

Common membrane phospholipids

Enzymes used to Dissect Phospholipid Structure