Natural Resources for our Healthy and Prosperous Generation Subagus Wahyuono Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia

Indonesia Indonesia is an archipelago comprising of approximately 17,508 islands. It encompasses 37 provinces with about 250 million people, making Indonesia is the world's fourth most populous country WestCentral East

We are blessed by the richnest of biodiversity on the world. This is one of Biodiversity Hot spots in Indonesia

Papaver somniverumSalix alba Nicotiana tabacum Taxus brevifolia Garlic Diospyros kaki (kesemek)

Traditional Medicine has been Practiced in Indonesia TRM practice Raw materials traditionally used Jamu Godog Registered Jamu preparation 1st lady Herbal Product Symbols

INTEGRATED MEDICINE TRADITIONAL MEDICINE WESTERN MODERN MEDICINE HARMONIZATION STANDARDIZATION Way to “Health for All ”

105 species were collected according to local Medicine Man, consisting of: – 3 families (Lycopodiaceae, Gleicheniaceae, Polypodiaceae) of Pteridophyte – 42 families of Spermatophyte Searching Potential Biodiversity from Central Kalimantan, guided by local medicine man

Yellow roots (Male) Arcangelisia flava (L.) Merr. (Fam. Menispermaceae) Cure Liver deseases Yellow roots (Female) Fibraurea chloroleuca Miers. (Fam. Menispermaceae) Cure Liver deseases 8-oxoprotoberberine HeLa Cells (20.08%) inhibited in vitro by this compound (500 µg/ml).

Renta (Local name) Combretum acuminatum Roxb. (Fam. Combretaceae) Protection for pregnant woman from Magic. Sinduk (Local name) (Garlic odor when the leaves craushed) Scorodocarpus borneensis Becc. (Fam. Olacaceae) Stomachache, antiflatullent

Saluang belong Male (local Name) Dictamnus albus L. (Fam. Rutaceae) Sexual enhancement for Men Pasak bumi/Tongkat Ali Eurycoma longifolia Jack. (Fam. Simaroubaceae) Sexual enhancement for men

Serai hutan (Local name) Celtis cinnamomea Lindl. ex Plancho (Fam. Ulmaceae) Smell likes Lemon Grass (Gramineae) Tapak barito (Local Name) Ficus deltoidea Jack. (Fam. Moraceae) Habitus : epifit Sexual enhancement for women

Principal Active Compounds THE ROLES OF NATURAL RESOURCES FOR HUMAN HEALTH AND PROSPERITY Flora, Animals Microorganisms Marine chemistry Human biochemistry DRUGS(Curative) PHYTOPHARMAKA (Plants) (Curative) Chemopreventive, Chemoprotective (Prevention) Methyl gallate

Curative v/s Preventive Secretion Procarcinogen Metabolic activation Ultimate Carcinogen Normal cells Initiation (1-2 days) Initiated cells Promotion (> 10 thn) Preneoplastic cells Neoplastic cells Progression (> 1 thn) Multi-stage of carcinogenesis Detoxification Kuratif

PRO-TECT : A product provides a broad spectrum flavonoid complex  Pro-tect  Pro-tect : Provides broad spectrum antioxidant nutrition of flavonoid.  Pro-tect  Pro-tect : Provides flavonoids present in the 8 standardized-qualified extracts  Flavonoid  Flavonoid : a phenolic type of compound present in plants, responsible for the bright colors of fruits, vegetables, useful for health promotion.

Pro-Tect contains :  Pycnogenol dan grape seed extract  Redbilberry extract  Grape skin extract  Green tea extract  Ginkgo biloba extract  Milk thistle (Sylibum marianum) extract  Citrus bioflavonoids

Red Billberry Gyngko biloba Silibum marianum

Silimarin

Lutein (a carrotenoid type of compound) Utilize the waste of carrot (Daucus carota) leaves

Proton NMR Lutein Scientific data is a must

OPTIMATION OF KESEMEK (Diospyros kaki Thunb.) LEAVES AS SUPPLEMEN PRODUCT TO PROMOTE HEALTH This sp. grows well in the northern of TNGM (Merapi Mt National Park) The fruits have economic values for people The leaves are discarded How to optimize economic values of the plant benefit for people surrondings

Similarity Index 79,2 % Similarity index 20,8 %

Herbs Garden Herbal Medicine Products Modern Medicine, Taxol But please not this kind of product.....

Thank you for your attention Research Laboratory Dept. of Pharmaceutical Biology Faculty of Pharmacy, GMU Unit-2, 1 st floor