Bio-organic molecules 1. carbohydrates 2. proteins 3. lipids 4. nucleic acids.

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Presentation transcript:

Bio-organic molecules 1. carbohydrates 2. proteins 3. lipids 4. nucleic acids

Protein function based on gene analysis Dr. Mani Subramanian; Celera Genomics NYTimes 2_14_01

Somatic cells are diploid

Chromosome 4 Huntington’s Disease autosomal dominant Ellis van Creveld Syndrome autosomal recessive

DNA protein

Transcription

Translation

Protein binding 1. specificity 2. affinity 3. saturation 4. competition

A + B C + D

+ 7 kcal/mol + H +

Energy is stored in chemical bonds

Enzyme substrate interactions 1. specificity 2. affinity 3. saturation 4. competition

M.R. Redinbo et al. (1998) Science 279: 1504 Enzyme: Topoisomerase I

Reaction rates What happens when you increase the amount of enzyme? What happens when you increase the amount of substrate?