Bryan Addeman April 6, 2010.  Background Theory  Motivation  Measurements  Moving Forward.

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Presentation transcript:

Bryan Addeman April 6, 2010

 Background Theory  Motivation  Measurements  Moving Forward

 Label specific metabolites with 13 C  12 C isotope is not magnetically active

 Natural abundance of 13 C is ≈ 1.11%  Amount of signal is related to gyromagnetic ratio (γ) & abundance ◦ γ H = (Mhz/T) ◦ γ 13C = (Mhz/T)  Hyperpolarization can give a factor of 10,000x more initial signal

 Inject sample mixed with free radical  Cool to 1.4 K in a High magnetic field  Bombard sample with microwaves  Mix with heated solution  Duration: 1.5 hours  Amount of Hyperpolarization decays with time (T1) Robarts DNP Hyperpolarizer

Spin-Spin RelaxationSpin-Lattice Relaxation T1T2

Effects of low magnetic fields on T1values for hyperpolarized 13 C Pyruvic Acid

 Hyperpolarized sample transport: ◦ B o : High (DNP) -> Low -> High (MRI)  What happens to the sample in transit?  T1 relaxation is a characteristic of the molecule that can be measured

SpinmasterOxford Instruments MQC  Variable magnetic field ◦ B o = T  Desktop NMR system ◦ B o = 0.55 T  Both devices can measure Signal amplitude at time intervals

B o =0.55, 13 C enriched Pyruvic Acid  Fit Equation  Non-Linear Least Squares Fit

SpinmasterMQC (0.55 Static Field) Field Strength (T) T1 (s)Fit Error (s)T1 (s)Fit Error (s)

 Need to take more measurements to understand the effects low field strengths on T1 values

Supervisors  Dr. Charles McKenzie  Dr. Lanette Friesen- Walder  Dr. Tim Scholl  Dr. Jake Onwuachi Lab  Curtis Wiens  Samantha Flood  Steven Yange  Elmer Soto  Trevor Wade