Integrating Cells into Tissues Chapter 22 Integrating Cells into Tissues Copyright (c) by W. H. Freeman and Company

Copyright (c) by W. H. Freeman and Company 22.0 Schematic overview of the types of molecules that bind cells to each other and to the extracellular matrix Copyright (c) by W. H. Freeman and Company Figure 22-1

Copyright (c) by W. H. Freeman and Company 22.1 There are five principal classes of cell-adhesion molecules (CAMs) Figure 22-2 Copyright (c) by W. H. Freeman and Company

22.1 Cadherins mediate Ca2+-dependent homophilic cell-cell adhesion Copyright (c) by W. H. Freeman and Company

22.1 N-CAMs mediate Ca2+-independent homophilic cell-cell adhesion Figure 22-3 Copyright (c) by W. H. Freeman and Company

Regulação da ligação de N-CAM por sialização Copyright (c) by W. H. Freeman and Company

22.1 Selectins and other CAMs participate in leukocyte extravasation Figure 22-4 Copyright (c) by W. H. Freeman and Company

22.1 Cadherin-containing junctions connect cells to one another Figure 22-5 Copyright (c) by W. H. Freeman and Company

A Matriz Extracelular (ECM) Presente em todos os tecidos Organiza as células em tecidos Coordena a função as células Providencia um caminho para a migração celular Moléculas na matriz activam vias de trasdução que regulam o crescimento, divisão e expressão génica das células As células interagem com a ECM através de CAM Principalmente integrinas Também selectinas e proteoglicanos Copyright (c) by W. H. Freeman and Company

22.2 Integrins mediate weak cell-matrix and cell-cell interactions Cell-matrix adhesion is modulated by changes in the activity and number of Integrins (plaquetas; maturação S.I.) De-adhesion factors promote cell migration and can remodel the cell surface Desintegrinas (pequenos péptidos com RGD) Proteases que degradam a ECM Matrix specific Metaloproteinases Fibrinogen Copyright (c) by W. H. Freeman and Company

22.2 Integrin-containing junctions connect cells to the substratum Figure 22-9 Copyright (c) by W. H. Freeman and Company

22.3 Collagen: the fibrous proteins of the matrix Copyright (c) by W. H. Freeman and Company

22.3 The basic structural unit of collagen is a triple helix Gly-Pro-X Glycine (R=H) Proline Collagen fibrils form by lateral interactions of triple helices Figure 22-11 Copyright (c) by W. H. Freeman and Company

Copyright (c) by W. H. Freeman and Company 22.3 The side-by-side interactions of collagen helices are stabilized by covalent bonds Figure 22-12 Copyright (c) by W. H. Freeman and Company

Copyright (c) by W. H. Freeman and Company 22.3 Assembly of collagen fibers begins in the ER and is completed outside the cell Figure 22-14 Copyright (c) by W. H. Freeman and Company

Copyright (c) by W. H. Freeman and Company 22.3 Mutations in collagen reveal aspects of its structure and biosynthesis Figure 22-15 Copyright (c) by W. H. Freeman and Company

22.3 Collagens form diverse structures Figure 22-16 Copyright (c) by W. H. Freeman and Company

Copyright (c) by W. H. Freeman and Company 22.4 Fibronectins bind many cells to fibrous collagens and other matrix components Copyright (c) by W. H. Freeman and Company