Vitamin D3 for Health, Cancer Prevention and Recovery Georgia Tetlow, MD

Fellow, University of Arizona Center for Integrative Medicine CEO, Founder of Philadelphia Integrative Medicine Clinical Assistant Professor of Rehabilitation Medicine Thomas Jefferson Medical College

Georgia Tetlow, MD Yoga Teacher for 20 years Mindfulness teacher

Mission Philadelphia Integrative Medicine offers a comprehensive approach to health and healing which recognizes the whole person, and champions self-care for health, illness recovery and prevention through education, inspiration and empowerment.

Mission Philadelphia Integrative Medicine offers a comprehensive approach to health and healing which recognizes the whole person, and champions self-care for health, illness recovery and prevention through education, inspiration and empowerment.

Agenda What’s an integrative approach? Diet and Cancer Cancer Vitamin D, Vitamin D and Cancer How much? – Working with your doctor Q & A

Agenda What’s an integrative approach? Diet, and Diet and Cancer Vitamin D Vitamin D and Cancer How much? – Working with your doctor Q & A

Integrative Medicine Best of conventional and evidence based alternative

Integrative Medicine Treatments that are Safe Effective Compatible with conventional treatment

Innate ability to heal

“Integrative medicine honors the innate ability of the body to heal, values the relationship between patient and physician, and integrates complementary and alternative medicine to support the organism and facilitate healing.” --- Victoria Maizes, MD University of Arizona Center for Integrative Medicine

Food as medicine Nutrigenomics

“There is now good evidence that nutrition has significant influences on the expression of genes, and, likewise, genetic variation can have a significant effect on food intake, metabolic response to food, individual nutrient requirements…” Ferguson LR., Nutrigenomics: integrating genomic approaches into nutrition research., Mol Diagn Ther. 2006;10(2):101-8)

Diet and cancer A wealth of evidence points to diet as one of the most important modifiable determinants of the risk of developing cancer… Ross, SA., Nutritional Genomic Approaches to Cancer Prevention Research., Exp Oncol Dec;29(4):250-6.

VITAMIN D3 Sunlight Diet – Fatty fish, fish liver oils – Fortified foods Milk, yogurt, cereals, orange juice Supplements—from fat of lambs wool Hormone

VITAMIN D3 Metabolized by liver, kidneys, colon, prostate, breast, lung, pancreas Drug interactions? – Steroids like prednisone – Some weight loss/cholesterol lowering drugs – Phenobarbital and Dilantin (phenytoin) – Anti-tuberculosis drugs – Statin medications and thiazide diuretics (mild increase)

VITAMIN D3 Vitamin D3 as calcitriol indirectly represses and activates oncogenes and tumor suppression genes Vitamin D compounds inhibit cancer growth and even kill cancer cells in vitro and in vivo

VITAMIN D3 Anti-proliferative--induce differentiation

VITAMIN D3 Anti-proliferative--induce differentiation

VITAMIN D3 Normal blood smear

VITAMIN D3 Chronic myelogenous leukemia

VITAMIN D3

Induction of molecule that restrains cell growth (cancer) – vitamin D receptor competes with cancer transcription factor that causes proliferation Inhibits angiogenesis Encourages normal cell cycle—including cell death Cancer J. 2010;16(1):1-9

VITAMIN D3 Considerable data for role of Vitamin D3 is cancer therapy and prevention No well designed trial of optimal vitamin D has ever been conducted Should be studied as a cancer drug – Single agent or in combination – Define optimal dose Cancer J. 2010;16(1):1-9

You and Vitamin D How much should I take? What form of vitamin D? What’s my optimal blood level?

Dose Institute of Medicine (age 9 and up): – minimum 600IU/day – Upper limit of normal 4000IU/day Safe level: 2,000IU daily Need blood level to achieve target range Clinicians have different target ranges

VITAMIN D3 Blood test: 25-OH vitamin D

VITAMIN D3

What kind? Replete all fat soluble vitamins Get A/D3/K1/K2 Vitamin D Complex

If there are profits from supplement sales, proceeds go to free educational programs like this one

Where Proceeds for educational programs!! Code: GT190 10%off

Agenda What’s an integrative approach? Diet and Cancer Cancer Vitamin D, Vitamin D and Cancer How much? – Working with your doctor

Monthly webinars—spread the word! September: Stress Reduction with Dr. Georgia: A Holistic Path for a Modern Lifestyle – Friday, 9/28, 12-1pm October: An Integrative Approach to Weight Loss Recording

Handouts – Best Amount of D3 for a Breast Cancer Survivor – Vitamin D Prevents Colorectal Cancer – Vitamin D Q&A