Case 5 M, 78 ys Violaceous plaque on the penis History of nodal Mantle Cell Lymphoma (courtesy Prof. A. Maiorana)

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Case 5 M, 78 ys Violaceous plaque on the penis History of nodal Mantle Cell Lymphoma (courtesy Prof. A. Maiorana)

CD20

CD3

CD5

Bcl-6

Cyclin-D1

Mib-1

DIAGNOSIS  Cutaneous localization of Mantle Cell Lymphoma Mantle Cell Lymphoma  FISH: presence of t(11;14)(q13;q32)

t(11;14)(q13;q32)  Translocation between IGH and cyclin D1 (CCND1) genes  It causes overexpression of CCND1 mRNA and protein cyclin D1  Cyclin D1 overcomes the cell cycle suppressors RB1 and p27/kip1  MCL: other secondary chromosomal aberrations

Mantle Cell Lymphoma  Main differential diagnoses: - B-CLL: cyclin-D1 -; no t(11;14)(q13;q32) - B-lymphoblastic lymphoma: TdT +; CD5 - cyclin-D1 - - Blastic plasmocytoid dendritic cell neoplasm: CD4 +; CD56 +; CD Merkel cell carcinoma: CK20 +; NF +; chromogranin +